The Extent of the Uptake of Plasmid Into the Skin Determines the Immune Responses Induced by a DNA Vaccine Applied Topically Onto the Skin

    January 2011 in “ Journal of Pharmacy and Pharmacology ”
    Zhen Yu, Woon-Gye Chung, Brian R. Sloat … Zhengrong Cui
    Studysummary This study found that inducing hair follicles into the anagen stage by plucking significantly enhances antibody responses in mice after topical DNA vaccine application, compared to retinoic acid or TPA treatments.
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    Research cited in this study 5

    1. Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    2. Immunization by Application of DNA Vaccine onto a Skin Area Where the Hair Follicles Have Been Induced into Anagen-Onset Stage Molecular therapy · 2007
    3. 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    4. Efficient Delivery of Transgenes to Human Hair Follicle Progenitor Cells Using Topical Lipoplex Nature biotechnology · 2000
    5. Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles Differentiation · 1994