Research Advances on Postbiotics in Promoting Skin Wound Healing: Mechanisms, Formulations, and Clinical Translation

    August 2026 in “ Frontiers in Immunology ”
    Yu Xing, Jinyu Song, Bingbing Shang … Binbin Hou
    Studysummary This review explores the emerging role of postbiotics—such as inactivated bacteria, cell components, and metabolites—in enhancing wound healing and skin microbiome health, highlighting evidence from various preclinical and preliminary clinical studies.
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    Research cited in this study 8

    1. The Regenerative Wound Healing Effects and Molecular Mechanism of Isaria Cicadae Miquel Rice Fermentation Extract Applied Microbiology and Biotechnology · 2025
    2. Type III Collagen Regulates Matrix Architecture and Mechanosensing During Wound Healing Journal of Investigative Dermatology · 2024
    3. Biotransformation of Cacumen Platycladi Extract by Lactiplantibacillus Plantarum CCFM1348 Promotes Hair Growth in Mice Journal of Agricultural and Food Chemistry · 2024
    4. Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling Frontiers in bioengineering and biotechnology · 2022
    5. Macrophage Related Chronic Inflammation in Non-Healing Wounds Frontiers in Immunology · 2021
    6. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    7. Obstruction of Granulation Tissue Formation Leads to Delayed Wound Healing After Scald Burn Injury in Mice Burns & Trauma · 2021
    8. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017