Metabolite Screening of Aromatic Amine Hair Dyes Using In Vitro Hepatic Models
October 2009
in “
Xenobiotica
”
aromatic amine hair dyes toluene-2,5-diamine p-aminophenol m-aminophenol p-methylaminophenol N,N′-bis(2-hydroxyethyl)-p-phenylenediamine 1-hydroxyethyl-4,5-diaminopyrazole 4-amino-2-hydroxytoluene 2-methyl-5-hydroxyethylaminophenol phenyl methyl pyrazolone oxidative metabolism human liver microsomes hepatocytes
Studysummary This study found no evidence that the tested hair dye ingredients undergo hepatic metabolism to reactive oxidized metabolites in human liver microsomes and hepatocytes.
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