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research Patch testing with hair cosmetic series in Europe: a critical review and recommendation

47 citations , June 2015 in “Contact Dermatitis”

This review discusses the need for an updated 'European hair cosmetic series' to include common contact allergens and remove outdated substances based on current evidence and regulations, but it reports no new results.

research Metabolite screening of aromatic amine hair dyes usingin vitrohepatic models

16 citations , October 2009 in “Xenobiotica”

This study found no evidence that the tested hair dye ingredients undergo hepatic metabolism to reactive oxidized metabolites in human liver microsomes and hepatocytes.

research Patch tests with commercial hair dye products in patients with allergic contact dermatitis to para-phenylenediamine

6 citations , January 2016 in “Indian Journal of Dermatology Venereology and Leprology”

This study found that the majority of "hypoallergenic" hair dyes still triggered allergic reactions in patients sensitive to para-phenylenediamine.

research Patterns of Sensitization and Cross-Reactivity in Hair Dye Allergy: An 18-Year Tertiary-Center Experience from Greece.

February 2026 in “PubMed”

This study reported that para-phenylenediamine and toluene-2,5-diamine are the main sensitizers in hair dye-related allergic contact dermatitis, with significant cross-reactivity to several other compounds.

research A clinical evaluation of a permanent hair dye designed to reduce allergic contact dermatitis and hair damage

9 citations , July 2022 in “Journal of Cosmetic Dermatology”

In this study, an ammonia-free and PPD-free permanent hair dye was tested on 50 ethnically diverse females, showing no cases of contact dermatitis and significant improvements in hair shine, color, moisturization, porosity, and combability after two dyeing sessions.

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