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research Metabolite screening of aromatic amine hair dyes usingin vitrohepatic models

16 citations , October 2009 in “Xenobiotica”

This study found no evidence that the tested hair dye ingredients undergo hepatic metabolism to reactive oxidized metabolites in human liver microsomes and hepatocytes.

research Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride.

20 citations , October 1995 in “PubMed”

This study identified CYP3A4 as a key isozyme involved in the oxidative metabolism of finasteride in human liver microsomes.

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

25 citations , February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, topical application of the SCD1 inhibitor XEN103 significantly reduced sebaceous gland size and number in mouse skin, suggesting potential local therapeutic effects for acne treatment without systemic side effects.

research Albendazole treatment of echinococcosis in humans: Effects on microsomal metabolism and drug tolerance

61 citations , March 1990 in “Clinical pharmacology and therapeutics/Clinical pharmacology & therapeutics”

In this study, albendazole treatment in patients with hydatid disease was associated with decreased microsomal enzyme function and induced its own metabolism, but also showed potential hepatotoxicity and severe side effects, necessitating careful monitoring.

research A complete guide to human microbiomes: Body niches, transmission, development, dysbiosis, and restoration

72 citations , July 2022 in “Frontiers in Systems Biology”

This review provides a comprehensive guide to the human microbiome and reports no new experimental results; it highlights the impact of modern lifestyles on microbial homeostasis and the necessity of conservation efforts.

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community DHT Itch and Oily Scalp Explained (and how to fix it)

90 upvotes 3 months ago

Malassezia overgrowth can worsen oily scalp and inflammation, contributing to hair loss. Treatments include antifungal shampoos, C6/C8 MCT oil, low-dose isotretinoin, finasteride, and dutasteride.

community Oral Fin+Min: Digital microscope scalp review - Day 0 Vs 3 Months

1399 upvotes 1 year ago

A user used oral finasteride and minoxidil for hair loss, seeing new hair growth under a microscope but no visible change. Commenters debated if the growth was real hair or fibers, and the user will update every 90 days.

community We live in the weirdest time to suffer Androgenetic Alopecia and this weird subreddit will probably be of some historic interest in the future.

in Chat 212 upvotes 1 year ago

Hair loss treatments like finasteride, minoxidil, and RU58841 are becoming more known, but many remain unaware of their effectiveness. There is hope for future advancements despite skepticism and misconceptions about current treatments.

community Can liver problems be associated with response to the oral minoxidil?

in Research 147 upvotes 8 months ago

Liver problems may reduce the effectiveness of oral minoxidil due to impaired SULT1A1 enzyme activity, which is crucial for converting minoxidil to its active form. This reduction in enzyme function can significantly decrease the drug's effectiveness in promoting hair growth.

community Is it possible to transplant mice skin into human body?

in Transplants 47 upvotes 11 months ago

Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.

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Learn

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learn Bicalutamide

What results can you expect from using bicalutamide on your scalp? There is no published human study of bicalutamide applied to the scalp for hair loss, no licensed topical product and no established dose, so no result can be predicted from it. The evidence that exists is for the oral tablet in women, which is a prescription drug requiring liver monitoring and contraindicated in pregnancy.

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