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    Development of Fluridil, a Topical Suppressor of the Androgen Receptor in Androgenetic Alopecia

    July 2003 in “ Drug Development Research ”
    Allen L. Seligson, Brian K. Campion, Jason W. Brown … Milos Sovak
    Studysummary In this study, using a novel topical androgen receptor suppressor, fluridil, significantly increased the percentage of growing hairs in males with androgenetic alopecia without systemic absorption or adverse side effects.
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    Research cited in this study 14

    1. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    2. Testosterone Levels in Healthy Men and the Relation to Behavioral and Physical Characteristics: Facts and Constructs European journal of endocrinology · 2001
    3. Treatments for Androgenetic Alopecia and Alopecia Areata Drugs · 2001
    4. Lack of Effect of Topical Finasteride Suggests an Endocrine Role for Dihydrotestosterone Fertility and Sterility · 2000
    5. Androgen Receptor Antagonists Structure-Activity Relationships Current Medicinal Chemistry · 2000
    6. New Topical Antiandrogenic Formulations Can Stimulate Hair Growth in Human Bald Scalp Grafted Onto Mice International Journal of Pharmaceutics · 2000
    7. Treatment of Hair Loss The New England Journal of Medicine · 1999
    8. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    9. Evaluation of RU58841 as an Anti-Androgen in Prostate PC3 Cells and a Topical Anti-Alopecia Agent in the Bald Scalp of Stumptailed Macaques Endocrine · 1998
    10. A Controlled Study of the Effects of RU58841, a Non-Steroidal Antiandrogen, on Human Hair Production by Balding Scalp Grafts Maintained on Testosterone-Conditioned Nude Mice British Journal of Dermatology · 1997
    11. Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque Endocrinology · 1997
    12. Topical Finasteride in the Treatment of Androgenic Alopecia: Preliminary Evaluations After a 16-Month Therapy Course Journal of Dermatological Treatment · 1997
    13. Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994
    14. RU 58841, A New Specific Topical Antiandrogen: A Candidate of Choice for the Treatment of Acne, Androgenetic Alopecia, and Hirsutism The Journal of Steroid Biochemistry and Molecular Biology · 1994

    Related research 1

    1. Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear Journal of Investigative Dermatology · 1998