Insights Into Structural and Proteomic Alterations Related to pH-Induced Changes and Protein Deamidation in Hair

This study investigates the effects of varying pH levels on hair structure and proteins, using scanning electron microscopy and mass spectrometry-based proteomics. It finds that extreme acidic (pH 3) and alkaline (above pH 8) conditions significantly impact hair morphology and proteins, particularly causing deamidation of keratins and keratin-associated proteins. In contrast, pH levels between 5 and 7 have minimal effects, suggesting that haircare products within this pH range are optimal for maintaining hair health. The research underscores the importance of pH in hair care, recommending products with a neutral pH to preserve hair integrity.