Label Retaining Cells with Myoepithelial Characteristics from the Proximal Acinar Region Define Stem Cells in the Sweat Gland

September 2013 in “ PLoS ONE ”

Yvonne Leung, Eve Kandyba, Yibu Chen, Seth Ruffins, Krzysztof Kobielak

label retaining cells LRCs sweat glands stem cells myoepithelial characteristics H2BGFP keratin 15 epidermal homeostasis wound healing trans-differentiate hair follicles Bone Morphogenetic Protein BMP pathway BMP receptor 1A skin appendages keratin BMP

Studysummary This study found that sweat gland stem cells primarily maintain sweat gland homeostasis but can trans-differentiate to aid in epidermal healing and regenerate diverse skin structures under certain conditions.

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