The Role of Protein Lactylation in Skin Diseases: From Molecular Mechanisms to Potential Therapeutics

    July 2026 in “ Frontiers in Immunology ”
    Y Zhang, Zhinan Shi, Xiaohui Mo … 潘展砚
    Studysummary This review summarizes recent findings on the role of lactylation, a novel post-translational modification, in skin diseases, suggesting its potential as a therapeutic target by linking metabolism, epigenetic regulation, and inflammatory processes.
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    Research cited in this study 7

    1. Lactate in Skin Homeostasis: Metabolism, Skin Barrier, and Immunomodulation Frontiers in Immunology · 2025
    2. Autophagy Induces Hair Follicle Stem Cell Activation and Hair Follicle Regeneration by Regulating Glycolysis 2024
    3. LSD1 Interacting With HSP90 Promotes Skin Wound Healing by Inducing Metabolic Reprogramming of Hair Follicle Stem Cells Through the c-MYC/LDHA Axis ˜The œFASEB journal · 2023
    4. Human Hair Follicles Operate an Internal Cori Cycle and Modulate Their Growth via Glycogen Phosphorylase Scientific Reports · 2021
    5. Short- and Long-Term Effects of Two Emollients on Itching and Skin Restoration in Xerotic Eczema Dermatologic therapy · 2018
    6. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    7. Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells Journal of Investigative Dermatology · 1996