1113 citations
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August 1999 in “The New England Journal of Medicine”
This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hairfollicle research.
This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.
854 citations
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February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”
This review summarizes recent advances in understanding the molecular mechanisms of hairfollicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.
Hairfollicles can store waste, potentially leading to hair loss, and treatments like DHT blockers and Minoxidil are suggested. Scalp inflammation and sensitivity to DHT also contribute to hair loss, and addressing these factors with a clinician is recommended.
Hairfollicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.
Hairfollicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.
Hairfollicles can experience regrowth with treatments like finasteride, minoxidil, Nizoral, dermarolling, collagen, and biotin, but some may not fully recover. Expectations should be managed as full regrowth to teenage levels may not be possible.
Hairfollicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.
Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.