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Glossary Type III Collagen

Type III collagen is a fibrillar collagen that plays a crucial role in the structural integrity of various tissues, including skin, blood vessels, and hair follicles. It is particularly relevant to hair biology as it contributes to the extracellular matrix of the dermal papilla, which is essential for hair follicle development and cycling. Distinguishing characteristics of type III collagen include its ability to form reticular fibers, providing support and elasticity, and its presence in tissues undergoing rapid growth or repair, making it significant in the context of hair loss and regeneration.

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research Distribution of Type XII and XIV Collagens in Bovine Dermis and Hair Follicles

September 2001 in “Connective tissue”

Type XII and XIV collagens help maintain hair follicle structure in bovine skin.

research 115 Distributions of type XII and XIV collagens in adult skin and the anagen hair follicle

July 1995 in “Journal of Dermatological Science”

research Skin-permeable liposome improved stability and permeability of bFGF against skin of mice with deep second degree scald to promote hair follicle neogenesis through inhibition of scar formation

26 citations , September 2018 in “Colloids and Surfaces B: Biointerfaces”

This study reported that a novel liposomal formulation, SP-bFGF-SF-LIP, enhanced bFGF stability and skin permeability, significantly improving hair follicle recovery and wound healing in a mouse model.

research Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia

25 citations , June 2018 in “Journal of The American Academy of Dermatology”

This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.

research Prediction and Demonstration of Retinoic Acid Receptor Agonist Ch55 as an Antifibrotic Agent in the Dermis

3 citations , February 2023 in “Journal of Investigative Dermatology”

Ch55 may help reduce skin scarring and fibrosis.

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community DUPA, Non Responders and Connective Tissue Disorders

8 upvotes 1 year ago

A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

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