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Glossary Topical Finasteride

medication applied to the scalp to treat hair loss

Topical Finasteride is a medication applied directly to the scalp to treat hair loss, particularly androgenetic alopecia (male or female pattern baldness). Unlike oral finasteride, which can have systemic side effects, the topical form aims to reduce these risks by delivering the drug directly to the affected area, thereby minimizing its absorption into the bloodstream.

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community Topical finasteride (P-3074) inhibits scalp DHT up to 70%

in Finasteride/Dutasteride 20 upvotes 7 months ago

Topical finasteride (P-3074) can inhibit scalp DHT by up to 70%, with some users experiencing systemic absorption similar to oral use. Users discuss varying application frequencies and concentrations, with some noticing side effects when overused.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community How much scalp dht does dutasteride 1mg, 1.5mg, and 2mg block?

in Finasteride/Dutasteride 12 upvotes 7 months ago

Dutasteride at 0.5mg blocks 50% of scalp DHT, while higher doses like 1mg and 2.5mg block more, with 2.5mg blocking up to 80%. Some users report better results with lower doses, and there's confusion about the effectiveness of different dosages on scalp versus serum DHT.

community Topical Finasteride dose doubts

3 weeks ago

A user is considering using a topical compound of 0.25% finasteride and 5% minoxidil for hair loss, concerned about side effects experienced with oral finasteride. Other users suggest starting with a lower concentration and possibly diluting the solution to minimize side effects.

community Topical finasteride - Can anyone here share their results?

4 upvotes 3 weeks ago

Topical finasteride combined with oral minoxidil is used by some for hair loss, with mixed results; some users report success while others find it difficult to apply. Alternatives like oral finasteride and microneedling are also considered, with some users experiencing hair stabilization and new growth.

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Research

5 / 1000+ results

research Pharmacodynamics and pharmacokinetics of P-3074, a new finasteride topical solution, administered at four different doses

January 2014

P-3074 effectively blocks scalp DHT better than oral finasteride.

research Sparse hair in a female toddler

April 2013

Iron supplements may reverse premature graying in iron-deficient individuals; ingrown nails are common in diabetics with certain risk factors; topical finasteride may reduce scalp DHT as effectively as oral finasteride; monilethrix treatment is challenging but some medications can help.

research A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers

50 citations , July 2014 in “International Journal of Clinical Pharmacology and Therapeutics”

This study found that both topical and oral finasteride significantly reduced plasma DHT after one week, with lower finasteride plasma exposure for the topical formulation.

research Single and repeated dose of finasteride topical solution in subjects with androgenetic alopecia: A pharmacokinetic and pharmacodynamic study

February 2013 in “Journal of The American Academy of Dermatology”

Finasteride solution helps treat hair loss.

research A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

14 citations , October 2020 in “Natural Products and Bioprospecting”

This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.

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learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

Are there really risks with topical finasteride? Reports on topical finasteride describe scalp irritation and dermatitis as the effects specific to it, and blood levels lower than the oral drug; whether the oral drug's systemic side effects (sexual, mood, suicidal-thought, cognitive and breast/semen effects, some reported to persist after stopping) are genuinely rarer on the topical form has not been measured in a trial powered to answer it. Both forms are prescription-only and contraindicated around pregnancy.
Does the vehicle change how much topical finasteride is absorbed? Formulation sources describe propylene glycol and microemulsion vehicles as increasing how much topical finasteride crosses the skin, but better penetration has not been shown to mean better hair results, and it also raises systemic exposure. The vehicle and strength are decisions for a prescriber or compounding pharmacist.
Is Finasteride unbeatable or are there equally powerful alternatives? Finasteride has the longest record of trial evidence in male androgenetic alopecia; in pooled 24-week trials dutasteride increased hair counts more, and minoxidil, topical finasteride, PRP, LLLT and microneedling have supporting studies. Regulators warn that finasteride can cause sexual side effects, depression and suicidal thoughts that may persist after stopping, its label also lists breast, semen and other physical effects, and dutasteride now carries a precautionary mood warning; both are prescription-only, and dutasteride and oral minoxidil are off-label for hair loss.

learn Bicalutamide

Is topical bicalutamide a safer alternative to finasteride? There is no published human trial of topical bicalutamide for hair loss, and no licensed topical product exists, so it cannot be called safer than finasteride — or shown to work at all. Oral finasteride has decades of trial data with a documented side-effect profile, and topical finasteride has a phase III trial behind it.

learn Fluridil

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

learn Clascoterone

Topical androgen-receptor blocker, approved as an acne cream

learn Pyrilutamide

Experimental topical anti-androgen, also known as KX-826

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Minoxidil

Vasodilator used on the scalp and, at low doses, as a tablet

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Experts

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Hair Loss Specialist
Tomica LaTrice
Atlanta, GA, United States

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Tomica LaTrice