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research Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis

122 citations , November 2014 in “BMC Medicine”

This research observed that oral testosterone replacement therapy significantly increases cardiovascular risk, while effects of injected or transdermal therapy on cardiovascular risk were not significant, prompting further investigation into these methods.

research Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1

27 citations , February 2005 in “Journal of Cellular Biochemistry”

This study found that rat male costochondral chondrocytes, unlike female chondrocytes, respond to testosterone through metabolism to dihydrotestosterone, which shows a maturation-state dependent effect in male growth plate cells.

research The serum evaluation of sex hormones including DHEAs, DHT, testosterone in oral lichen planus patients

1 citations , May 2025 in “Scientific Reports”

In this study, researchers found no significant differences in serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology linked to the condition.

research The Serum Evaluation of Sex Hormones Including DHEAs, DHT, Testosterone in Oral Lichen Planus Patients

April 2025

In this study, researchers found no significant differences in the serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology is associated with this condition.

research The Effect of Finasteride on the Secretion of Testosterone, DHT, LH, FSH and Tissue Factors in the Testis of NMRI Mice:

June 2021 in “Archives of Advances in Biosciences”

This study suggests that finasteride at doses of 5 mg/kg BW or higher may adversely affect spermatogenesis and male fertility in NMRI mice.

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Community Join

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community Low testosterone and dht. What should I do?

in Finasteride/Dutasteride 7 upvotes 2 years ago

The user has low testosterone and DHT levels and is considering taking finasteride for Norwood 2 hair loss with diffuse thinning. They are seeking advice on whether low DHT indicates high sensitivity to DHT in the scalp and opinions on their lab values.

community My DHT levels on 1400mg testosterone per week and 0.5mg dutasteride daily

346 upvotes 2 months ago

A bodybuilder uses 1400mg testosterone weekly, 400mg equipoise, and GH, with 0.5mg dutasteride daily to stabilize hair loss and manage DHT levels. The user reports no side effects from dutasteride and finds it effective, while also discussing costs and effectiveness of other treatments like RU58841 and minoxidil.

community Can testosterone alone cause hair loss even after nuking DHT?

in Research/Science 26 upvotes 7 months ago

Testosterone can still cause hair loss even when DHT is blocked by dutasteride, especially if hair follicles are sensitive. Topical treatments like RU58841 or pyrilutamide may help, but their long-term effectiveness is uncertain compared to dutasteride.

community How does testosterone and dht work?

14 upvotes 4 weeks ago

Hair loss is influenced by follicle sensitivity to DHT, which increases with age, rather than just testosterone levels. Treatments like finasteride and hair transplants are used to manage hair loss, with transplants needing medication to protect surrounding sensitive hair.

community Do creatine increase testosterone and dht?

4 upvotes 5 months ago

Creatine does not increase testosterone or DHT, and there is no evidence it causes hair loss. Some users report improved gym performance and mood with creatine, while others are concerned about potential hair loss, but scientific research does not support these concerns.

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Learn

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Ecklonia Cava

How does Ecklonia Cava help slow down hair loss in people with androgenetic alopecia? Ecklonia cava may slow hair loss by inhibiting the enzyme that converts testosterone to DHT.

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Saw Palmetto

a natural and far less effective alternative to Finasteride

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.

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