Can testosterone alone cause hair loss even after nuking DHT?
    Research/Science 1/27/2026

    At a glance
    In this question or advice post, the primary subjects mentioned are
    πŸ’Š Dutasteride (oral) 0.5 mg daily
    πŸ’§ RU58841 (topical)
    πŸ’§ Pyrilutamide (topical)
    the tone is 😐 neutral.

    Other terms

    Testosterone can still cause hair loss even when DHT is blocked by dutasteride, especially if hair follicles are sensitive. Topical treatments like RU58841 or pyrilutamide may help, but their long-term effectiveness is uncertain compared to dutasteride.
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