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Did you mean Terminal Hair Follicles?

Glossary Terminal Hair Follicles

structures producing thick, pigmented hair on scalp and body

Terminal hair follicles are the structures in the skin that produce terminal hair, which is the thick, pigmented hair found on the scalp, face, armpits, and pubic area. Unlike vellus hair, which is fine and light, terminal hair is coarser and darker, and its growth is influenced by hormonal changes, particularly androgens.

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Research

5 / 1000+ results

research Hair(y) Matters in Melanoma Biology

7 citations , May 2020 in “Trends in molecular medicine”

This study explored the immune environment of the hair follicle's bulge region and suggested that its unique signaling may prevent melanoma formation by lacking necessary proinflammatory signals for full oncogenic transformation, indicating potential strategies for melanoma prevention by replicating this immune-privileged environment.

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

This study observed that CIP/KIP proteins play a significant role in regulating cell cycle arrest and differentiation in human hair follicles, supporting hair growth and formation in the anagen phase.

research Histomorphological features of the skin in neonate rabbits

October 2024 in “International Journal of Comprehensive Veterinary Research.”

In this study, researchers examined the skin of neonatal rabbits and found that most hair follicles were in the terminal stage, with hair shafts protruding through the epidermis, but noted the absence of sweat glands.

research Histopathology of alopecia areata, acute and chronic: Why is it important to the clinician?

43 citations , May 2011 in “Dermatologic Therapy”

This article discusses the phases and histological features of alopecia areata and reports no new clinical findings; the authors emphasize recognizing these phases for accurate diagnosis.

research Pharmacological aspects of hair follicle growth

7 citations , January 1989

Minoxidil and 4-MA can help treat hair loss.

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Community Join

5 / 562 results

community Minoxidil experiment on single hair follicle

1689 upvotes 1 year ago

Minoxidil was applied to a single miniaturized hair follicle over four months, resulting in less miniaturization but not yet terminal growth. The user used a 5% minoxidil solution, specifically the Regaine brand, and observed changes using a handheld WiFi microscope.

community Confused why people are calling PP405 a cure...it never claimed to be able to undo miniaturization or revert vellus back to terminal hairs. It seems to be more of a growth stimulant like minoxidil.

in Research/Science 55 upvotes 1 year ago

PP405 is not a cure for hair loss but may reactivate dormant hair follicles, similar to minoxidil. It is unlikely to help with miniaturized or vellus hairs and is still in trial phases, with availability expected around 2030.

community Found a slide summary for PP405

35 upvotes 5 months ago

PP405 shows promise in stimulating new terminal hair growth by activating dormant follicles, with no systemic adverse effects observed in a short-term trial. However, long-term efficacy remains unproven, and further trials are needed to confirm its potential as a hair loss treatment.

community What should i do while waiting

in General 143 upvotes 9 months ago

The user is seeking advice on preserving hair follicles at Norwood stage 6 or 7 while waiting for new treatments. They are considering using treatments like Minoxidil, finasteride, or RU58841.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 1 year ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

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