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Viable Terminal Scalp Hair Follicles Are Necessary and Sufficient for Clinical Efficacy of Finasteride in Male Pattern Hair Loss

research Viable terminal scalp hair follicles constitute a necessary and sufficient biological end‐organ that conditions clinical efficacy of finasteride in males with male pattern hair loss without implying reversal of miniaturized follicles

6 citations , June 2019 in “Skin Research and Technology”

In this study, finasteride treatment for two years did not significantly reverse miniaturized hair follicles in men with male pattern hair loss, challenging the "reversal hypothesis" as 79 out of 113 miniaturized hairs remained unchanged.

Maintenance of Optimized Hair Growth from Viable Terminal Scalp Hair Follicles at Baseline with Oral Finasteride in Male Pattern Hair Loss and First Evidence of a Drug Dependency and a Post-Finasteride Rebound Effect

research Maintenance of optimised hair growth from viable terminal scalp hair follicles at baseline with oral finasteride in male pattern hair loss and first evidence of a “drug dependency” and a post-finasteride “rebound effect”.

4 citations , May 2019 in “Skin Research and Technology”

This study found that male pattern hair loss worsened significantly after stopping finasteride, revealing a "rebound effect" where terminal hair transformed into miniaturized hair over 30 months off the drug.

research Evaluation of Hair Follicle Counts of Occipital Scalp Biopsies from Male Hair Transplant Patients in Thailand

1 citations , February 2023 in “Siriraj Medical Journal/San Sirirat”

This study found that Thai males with androgenic alopecia displayed lower average hair density in the occipital scalp compared to other Asian populations, but higher than those with advanced AGA.

research Variation of Hair Follicle Counts among Different Scalp Areas: A Quantitative Histopathological Study

11 citations , September 2021 in “Skin Appendage Disorders”

This study observed variability in hair density and types across different scalp areas in cadaver biopsies, providing reference values that could aid in diagnosing hair disorders in Asians.

research 564 Vertex and Occipital Intermediate and Terminal Hair Follicles from Androgenetic Alopecia Patients are Differentially Affected by Testosterone Ex Vivo

November 2022 in “Journal of Investigative Dermatology”

This study found that testosterone impacts hair follicles from different scalp regions differently in male pattern androgenetic alopecia, challenging the belief that occipital scalp follicles are androgen-insensitive.

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Community Join

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community 15 months topical 5% min and 0.5 dut. Is this also regrowth? Or could these grow into terminal hairs at some point?

4 upvotes 1 week ago

The user has been using topical 5% minoxidil and 0.5 mg dutasteride for 15 months, noticing stronger hair and some new growth. They have experienced hair loss for 10 years, underwent two hair transplants, and are seeing density improvements, particularly in the frontal scalp.

community Minoxidil experiment on single hair follicle

1689 upvotes 1 year ago

Minoxidil was applied to a single miniaturized hair follicle over four months, resulting in less miniaturization but not yet terminal growth. The user used a 5% minoxidil solution, specifically the Regaine brand, and observed changes using a handheld WiFi microscope.

community Confused why people are calling PP405 a cure...it never claimed to be able to undo miniaturization or revert vellus back to terminal hairs. It seems to be more of a growth stimulant like minoxidil.

in Research/Science 55 upvotes 1 year ago

PP405 is not a cure for hair loss but may reactivate dormant hair follicles, similar to minoxidil. It is unlikely to help with miniaturized or vellus hairs and is still in trial phases, with availability expected around 2030.

community BREAKTHROUGH: I’m a radiochemist and discovered a radioactive isotope scalp serum that OUTPERFORMS Minoxidil and 5-AR inhibitors! (Lab Data Inside)

in Satire 1 year ago

A satirical post where someone claims to have developed a radioactive isotope scalp serum using Polonium-210 that outperforms Minoxidil and finasteride for hair regrowth. The serum reportedly stimulates DNA repair in hair follicles, leading to significant hair density increase, but the post is met with skepticism and concerns about safety.

community Something I misunderstood about hair loss for a long time

176 upvotes 9 months ago

Hair follicles often go dormant rather than die, and treatments like minoxidil can help revive them. Scalp health and stimulation, such as massages and using products like sulphur soap, are also important for hair regrowth.

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