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Did you mean Small Molecule Inhibitor?

Glossary Small Molecule Inhibitor

blocks specific proteins or enzymes within cells

A Small Molecule Inhibitor (SMI) is a type of drug that can enter cells easily due to its low molecular weight and can interfere with specific proteins or enzymes to block their activity. These inhibitors are often used in treatments for various diseases, including cancer and autoimmune disorders, by targeting and disrupting specific pathways that contribute to disease progression.

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Research

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research Chemotherapy-induced iatrogenic injury of skin: New drugs and new concepts

19 citations , October 2011 in “Clinics in Dermatology”

This review discusses the cutaneous side effects of chemotherapy, noting that they frequently involve changes to skin, hair, and nails, and reports no new results.

research Molecular Targeted Agents and Biologic Therapies for Non-small Cell Lung Cancer

12 citations , December 2010 in “Journal of thoracic oncology”

This article organizes and lists ongoing and completed clinical trials of novel agents for lung cancer, serving as a reference tool with no new research findings reported.

research Cutaneous adverse effects of targeted therapies

192 citations , January 2015 in “Journal of the American Academy of Dermatology”

This review discusses skin-related toxicities associated with targeted cancer therapies and emphasizes the need for dermatologists to understand and manage these adverse effects, but reports no new experimental results.

research Molecular targeted therapies for cancer: Sorafenib monoï¿½therapy and its combination with other therapies (Review)

46 citations , February 2012 in “Oncology Reports”

This review summarizes existing studies on sorafenib, noting its promising effects in some cancers, but also highlights its limitations and potential synergy when combined with other anticancer treatments.

research Patient‐Level Adverse Event Patterns in a Single‐Institution Study of the Multi‐Kinase Inhibitor Sorafenib

10 citations , July 2016 in “Clinical and translational science”

In this study, sorafenib's common adverse events, like a hand-foot syndrome and diarrhea, were observed in distinct temporal and tissue distribution patterns, revealing new relationships among effects.

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