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Glossary Keratinization

process where skin cells produce keratin and become tough

Keratinization, also known as cornification, is the biological process by which keratin, a protective protein, is produced and accumulated in cells of the epidermis, the outermost layer of the skin. This process results in the formation of a tough, protective layer of dead cells that helps to prevent water loss and protect against environmental damage, pathogens, and physical abrasion.

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Research

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research Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions

2 citations , December 2023 in “International journal of molecular sciences”

This study reviews the complex keratinization process in the epidermis, detailing how various factors regulate keratinocyte differentiation and emphasizing the importance of understanding this process for the pathogenesis of skin disorders like ichthyoses and psoriasis.

research Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.

94 citations , October 1994 in “The Journal of Cell Biology”

This study demonstrates that overexpression of K16 in transgenic mice disrupts normal keratinization, leading to hyperkeratosis, acanthosis, and alterations in the skin's epithelial cells.

research Artificial Infestation of Sarcoptes scabiei (Acari: Sarcoptidae) in Rabbits Exhibits Progressive Pathological Changes, Apoptosis, and Keratinization in the Skin

1 citations , January 2023 in “International journal of molecular sciences”

This study found that S. scabiei infestation in rabbits leads to epidermal thickening possibly due to apoptosis-related proliferation and keratinization of the skin.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

TCDD changes skin gene expression and may harm skin health.

research Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition

3 citations , January 2025 in “Discovery Medicine”

This study found that glycolic acid treatment reduced oxidative stress and inflammation in UV-induced skin photoaging in rats, promoting collagen recovery and reducing photoaging signs, potentially by inhibiting the PI3K/Akt and NF-κB pathways.

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Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

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Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
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How does retinol improve scalp health and prepare the skin for other hair growth treatments? Retinol improves scalp health by promoting cellular turnover and reducing congestion.

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community Blaming Finasteride doesn't help you solve anything: dry eyes

51 upvotes 1 year ago

Finasteride is debated for causing dry eyes, with some users experiencing relief after stopping it, while others find no connection. Topical treatments like dutasteride and minoxidil are suggested as alternatives, with advice to consult medical professionals.

community Skin Aging and Minox

5 upvotes 11 years ago

The conversation is about concerns over skin aging from using minoxidil for hair loss, with the user planning to use a minimal amount to avoid side effects. Other users suggest that overuse may cause temporary skin dryness but not actual aging, and emphasize proper application.

community Scalp Skin Barrier Health and Hair Follicle Cycling: A Potential Overlooked Connection

in Technology 4 months ago

The conversation discusses the importance of scalp skin barrier health in hair follicle cycling, suggesting treatments like ceramides or niacinamide to support hair growth. It also mentions the use of finasteride for hair loss.

community Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

4 upvotes 1 year ago

Minoxidil can be effectively delivered through nanoemulsions containing eucalyptol or oleic acid, enhancing its diffusivity and targeting hair follicles. This contradicts the advice against mixing minoxidil with oils in topical formulations.

community Is there any good collagen to use for skin, nails, hair, and joints?

2 upvotes 1 month ago

Collagen supplements for improving skin, hair, nails, and joints. Recommendations include standard collagen peptide powder and Live Conscious collagen peptide, though some users doubt their effectiveness.

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SMP Specialist
Noelle Skin
Nice, France

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Noelle Skin