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    Glossary Keratinization

    process where skin cells produce keratin and become tough

    Keratinization, also known as cornification, is the biological process by which keratin, a protective protein, is produced and accumulated in cells of the epidermis, the outermost layer of the skin. This process results in the formation of a tough, protective layer of dead cells that helps to prevent water loss and protect against environmental damage, pathogens, and physical abrasion.

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    1. Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions International journal of molecular sciences · 2023 · 2 citations
    2. Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin. The Journal of Cell Biology · 1994 · 94 citations
    3. Artificial Infestation of Sarcoptes scabiei (Acari: Sarcoptidae) in Rabbits Exhibits Progressive Pathological Changes, Apoptosis, and Keratinization in the Skin International journal of molecular sciences · 2023 · 1 citations
    4. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin Journal of Investigative Dermatology · 1997 · 45 citations
    5. Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition Discovery Medicine · 2025 · 3 citations
    6. Embryonic keratinization in vertebrates in relation to land colonization Acta Zoologica · 2008 · 44 citations
    7. Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches Medical Science Monitor · 2024 · 18 citations
    8. Keratinization and its Disorders Oman Medical Journal · 2012 · 95 citations
    9. Penetration and Local Effect of Vitamin A on the Skin of the Guinea Pig., Experimental Biology and Medicine · 1954 · 45 citations
    10. Disorders of Keratinization American journal of clinical dermatology · 2004 · 44 citations
    11. Retinoids and Keratinization International Journal of Dermatology · 1988 · 32 citations
    12. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    13. Induction of Skin-Derived Precursor Cells from Human Induced Pluripotent Stem Cells PLOS ONE · 2016 · 21 citations
    14. A Heritable Keratinization Defect of the Superficial Epidermis in Norfolk Terriers Journal of Comparative Pathology · 2004 · 11 citations
    15. Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin International journal of molecular sciences · 2021 · 9 citations
    16. Structure and Function of the Skin Elsevier eBooks · 2009 · 6 citations
    17. Positive Impact of Fish Oil on Diabetic and Hypercholestrolemic Skin Disorders Journal of nutrition & health · 2015 · 1 citations
    18. Skin iconography analysis of traumatic anserine folliculosis: Skin image feature of TAF Skin Research and Technology · 2024
    19. Keratosis Pilaris Is a Keratinization of Hair Follicles International journal of integrated medical research · 2023
    20. Faculty Opinions recommendation of Hidradenitis suppurativa as a potential subtype of autoinflammatory keratinization disease. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2020
    21. Congenital and Hereditary Skin Diseases 2018
    22. 정상 및 배양 피부 , 수종 각화이상성 피부질환에서의 Skin Sulfhydryl Oxidase 발현에 관한 연구 Seoul National University Open Repository (Seoul National University) · 1995
    23. The evolution of healthy skin to acne lesions: a longitudinal, <i>in vivo</i> evaluation with reflectance confocal microscopy and optical coherence tomography Journal of the European Academy of Dermatology and Venereology · 2019 · 19 citations
    24. Molecular Genetics of Keratinization Disorders – What’s New About Ichthyosis Acta dermato-venereologica · 2020 · 18 citations
    25. Congenital and Hereditary Skin Diseases 2018
    26. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats PLoS ONE · 2016 · 127 citations
    27. The nude gene and the skin Experimental Dermatology · 2001 · 41 citations
    28. Histological and dermatoscopic description of sphynx cat skin Veterinary Dermatology · 2014 · 26 citations
    29. Melatonin Receptor MT1 is Expressed in Mouse Skin and In vitro Melatonin Treatment Enhances Whisker Growth Journal of clinical & experimental dermatology research · 2013 · 1 citations
    30. Expression of epidermal keratins and filaggrin during human fetal skin development. The Journal of Cell Biology · 1985 · 292 citations