learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
Search
forResearch
5 / 1000+ resultsresearch Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats
FGF5 gene mutations cause long hair in domestic cats.
research Sequence Analyses of Type I and Type II Chains in Human Hair and Epithelial Keratin Intermediate Filaments: Promiscuous Obligate Heterodimers, Type II Template for Molecule Formation and a Rationale for Heterodimer Formation
Type I and Type II keratin chains can form heterodimers despite sequence differences.
research Structural Hierarchy of Trichocyte Keratin Intermediate Filaments
Keratin proteins are crucial for hair growth and structure.
research Human Hair Keratin-Associated Proteins: Sequence Regularities and Structural Implications
Keratin-associated proteins help link filaments and affect keratin's strength.
research Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets with Alopecia in Four Egyptian Families: Report of Three Novel Mutations in the Vitamin D Receptor Gene
Three new gene mutations cause rickets and hair loss, treatable with high calcium and calcidol, but hair regrowth is rare.
Community Join
5 / 42 resultscommunity End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁
GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.
community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201
PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hair growth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.
community What happened to the big three? Ketoconazole is pretty magic for some and over the last few years it has been missing in people’s regiment quite a bit
Ketoconazole, once popular for hair health, is now less mentioned, with mixed reviews on its benefits for scalp health. Microneedling is discussed as a potential alternative to traditional treatments like finasteride and minoxidil, with varied opinions on its effectiveness.
community FCE 28260: A Forgotten 5α-Reductase Inhibitor
by
nkrata
in Research
330 upvotes
1 year ago FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community Is it possible for androgenic alopecia to begin at early adolescent years?
Hair loss can begin in early adolescence and cause mental anguish. Treatments mentioned include eating cruciferous vegetables, engaging in physical activity, and maintaining scalp hygiene.