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This study found that the transcription factor Lhx2 regulates Sonic Hedgehog signaling in mouse retinal progenitor cells, mainly by controlling the expression of co-receptors essential for effective pathway activation during early retinal neurogenesis.

This study reported that a new polymeric formulation for topical minoxidil delivery in an animal model improved hair growth and hair follicle formation more effectively than minoxidil in PBS, suggesting potential as a future hair loss treatment.

This study identified trichoscopy as a key diagnostic tool for erosive pustular dermatosis of the scalp and suggested high-potency steroids or tacrolimus as effective first-line treatments.

This study found that PIXE microanalysis effectively detected and quantified trace element changes in hair shafts, revealing a marked decrease in copper after treatment for green hair syndrome.

This study developed a quercetin-encapsulated and polydopamine-integrated nanosystem that reshapes the perifollicular microenvironment, showing potential for rescuing hair follicle viability and regenerating hair follicles in androgenic alopecia by scavenging reactive oxygen species and promoting angiogenesis.

This study reports that the autotaxin–LPA–LPA3 signaling pathway at the embryo-epithelial boundary plays a critical role in decidualization by up-regulating HB-EGF and COX-2 in the uterine epithelium.

PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.

PP405 may help hair growth by activating hair follicle stem cells.

Ixekizumab is effective and safe for patients who did not improve with etanercept treatment for psoriasis.

In this study, a new formulation of human placental extract showed antioxidant and neurite outgrowth activities, significantly reduced hair graying in mice, and alleviated neuropathy symptoms, suggesting potential therapeutic benefits.

This policy brief found that post-drug syndromes are under-recognized in current pharmacovigilance systems, leading to inadequate risk assessments and prolonged patient harm from persistent drug-induced conditions.

This article reports a case of erosive pustular dermatosis on the scalp of an elderly male, highlighting its complex diagnosis and successful treatment with high-potency topical corticosteroids.

In this study, researchers reported that the Pinkie mutation in mice, affecting RXRa activity, leads to skewed Th1 development and suggests RXRa's role in Th2 differentiation, impacting immune responses.

This case report describes a 29-year-old Japanese-Paraguayan man who experienced a relapse of leprosy 14 years after initial treatment, presenting with severe pain and skin lesions but no sensory impairment.

A specific gene variant is linked to heart disease, increased heart muscle, curly hair, and thick skin on palms and soles.

This study suggests that combining tranexamic acid with low-dose oral retinoids may offer moderate to good improvements for lichen plan pigmentosus, although larger trials are needed for confirmation.

Hair removal with intense pulsed light can cause rare skin lesions that are hard to fully treat.

This study reports a novel mutation in the TP63 gene associated with T and B cell lymphopenia in an EEC patient, suggesting that EEC diagnosis should include TREC assay and evaluation for immunodeficiency.

This study found that a new deoxycholic acid derivative may offer a similar prostatoprotective effect to finasteride with lower toxicity in rat models.

This study reports that VP-16-213 (etoposide) shows significant therapeutic activity in several cancers including small cell bronchogenic carcinoma and certain leukemias, with hematologic toxicity being the primary side effect.

In this study, overexpression of ornithine decarboxylase accelerated basal cell carcinoma in Ptch1+/– mice under UVB exposure, while its inhibition reduced tumor induction, suggesting potential chemoprevention strategies in humans.

This study found that dexpanthenol treatment reduced inflammation, oxidative stress, and apoptosis in rats, providing a protective effect against lipopolysaccharide-induced cardiac and endothelial damage.

Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.

This study found that PDCD4 protein expression is reduced in various skin cancers compared to normal skin, suggesting its potential role in preventing or treating certain skin cancers.

In this study, researchers observed that P2X3-immunoreactive fibers extensively innervate the epidermis of rats, suggesting a primary role in detecting noxious stimuli in cutaneous tissue.

This case report describes a 66-year-old woman diagnosed with porphyria cutanea tarda, characterized by painless vesicular lesions on sun-exposed areas and associated with hemochromatosis, and managed effectively with phlebotomy.

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

This study reports the first case of mandibuloacral dysplasia syndrome associated with MTX2 gene mutation in the Chinese population, expanding the known spectrum of MTX2 mutations.

This article discusses multiple minute digitate hyperkeratosis in a dermatological context and reports no new clinical findings; the authors focus on a descriptive review.

This study found that the antimicrobial peptide DPK-060 effectively reduced bacterial counts of Staphylococcus aureus and was safe for topical use in preclinical models, although nanocarrier encapsulation did not enhance its efficacy.