research Clascoterone: First Approval
This article reviews the development milestones of clascoterone up to its first approval for treating acne vulgaris, reporting no new clinical results for androgenetic alopecia.
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research Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist
This review highlights that clascoterone, a newly FDA-approved topical androgen antagonist, effectively reduces both non-inflammatory and inflammatory acne lesions with no systemic effects, making it a promising new option for acne treatment in both male and female patients.
research Androgen Receptor Inhibitors in the Treatment of Acne Vulgaris: Efficacy and Safety Profiles of Clascoterone 1% Cream
This review discusses the clinical trials of clascoterone 1% cream for acne vulgaris and reports no new results; the authors highlight its novel role as a topical antiandrogen.
research Journal of Pigmentary Disorders
This presentation highlighted future directions in acne care, emphasizing the roles of topical and oral antibiotics, as well as skin microbiome studies. It also described how clascoterone targets androgen receptors in hair follicles and sebaceous glands to reduce sebum production.
research BRIDGING THE GAP IN ACNE MANAGEMENT: A NARRATIVE REVIEW OF CURRENT THERAPIES AND THE EMERGENCE OF CLASCOTERONE
This source describes clascoterone, a new topical treatment for acne vulgaris that blocks androgen receptors to reduce sebaceous gland activity and inflammation, offering a lower risk of systemic side effects compared to oral treatments.
research Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments
Spironolactone is effective for treating female hair loss, with new treatments like clascoterone showing promise.
research TRADITIONAL AND ALTERNATIVE METHODS OF ACNE TREATMENT
This review discusses the multifactorial pathogenesis of acne and current treatment strategies including the use of isotretinoin and spironolactone, but reports no new clinical results.
research Editorial Note on Next-Generation Therapies and Advance Acne Treatment
This study reported that clascoterone cream reduced inflammatory and noninflammatory acne lesions in a trial with 1440 white males and non-pregnant females, showing it was well tolerated in these participants.
research Experimental and early investigational drugs for androgenetic alopecia
This review discusses current and emerging therapeutic strategies for androgenetic alopecia, noting limited evidence but suggesting areas such as prostaglandin analogs, PRP, and progenitor cell therapies as promising future directions.
research Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris
This review discusses the potential efficacy of topical antiandrogen therapies for treating androgenetic alopecia and acne vulgaris, finding promising results but highlighting the need for more comprehensive studies.
research Industry update: the latest developments in the field of therapeutic delivery, July 2018
This industry update reports on various advancements in therapeutic delivery during July 2018, highlighting active mergers, collaborations, and potential developments across fields like gene therapy, immuno-oncology, and rare diseases treatment; however, no new clinical results are presented.
research Nouvelles thérapeutiques dans la prise en charge de l’alopécie androgénétique
This thesis investigates the underlying mechanisms and treatment options for androgenetic alopecia, highlighting the molecular roles of androgens and genetic predispositions, and evaluates current and emerging therapies, such as PROTACs and Janus Kinase inhibitors, to enhance patient management.
research Hair loss with levetiracetam in five patients with epilepsy
This study reports that hair loss may be a rare side effect of levetiracetam in epilepsy patients and appears reversible upon dose reduction or cessation.
research Clascoterone Cream 1% in Acne Management: Case Series and Real-World Canadian Experience
In this case series, treatment with clascoterone cream 1% was reported to be effective and well tolerated for diverse acne vulgaris patients, improving clinical outcomes whether used alone or in combination with other therapies, and addressing various other skin conditions.
research Lymphoid Enhancer-binding Factor-1 (LEF1) Interacts with the DNA-binding Domain of the Vitamin D Receptor
This study discovered a novel interaction between the vitamin D receptor and LEF1, essential for normal Wnt signaling in keratinocytes, which is crucial for regular hair cycling.
research Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies
This review of acne management strategies highlights current treatments, such as topical and systemic therapies, procedural methods, and dietary changes, while also discussing emerging options like biologics and probiotics as potential future treatments, emphasizing personalized care due to acne's complex nature.
research Safety of Alopecia Treatments in Patients with Breast Cancer and High-Risk Women: A Review
Alopecia treatments like 5α-reductase inhibitors and spironolactone are safe for breast cancer patients and high-risk women.
research Recent Advances in Drug Development for Hair Loss
This review highlights the limitations of existing hair loss treatments like minoxidil and finasteride and suggests that future therapies may benefit from focusing on antibody and cell-based treatments, which offer targeted and potentially transformative options for managing hair loss disorders.
research Managing Common Dermatologic Needs in Transgender and Gender-Diverse Adolescents
Transgender and gender-diverse teens need specialized skin and mental health care.
research Real-World Experience of Clascoterone Cream 1% in Acne Management: Case Series and Canadian Experience
This case series involving 10 patients treated with clascoterone cream 1% for acne vulgaris found it effective and well-tolerated, regardless of severity, age, gender, or ethnicity, and noted additional benefits for related skin conditions.
research Hormonal Therapies for Acne: A Comprehensive Update for Dermatologists
This review updates dermatologists on both FDA-approved and off-label hormonal therapies, including combined oral contraceptives, clascoterone, and spironolactone, used for acne treatment, providing insights into emerging approaches for managing the condition.
research Can zinc depletion play a role in LEV-induced hair loss? Considerations from a case study
research LEVEL OF BENEFIT FROM FINANCIAL LEASING IN SMES IN THE INDUSTRIAL SECTOR
This review discusses the historical development and market presence of financial leasing, emphasizing its advantages, but reports no new research findings.
research A 57-Year-Old Male Retired Colonel with Acute Ankle Swelling
This case report describes a 57-year-old male who developed bilateral ankle swelling and pain, potentially linked to a recent episode of fever and chills following prostatitis treatment.
research GBP1 as a machine learning-prioritized biomarker and therapeutic target for epstein-barr virus-induced clear cell renal cell carcinoma: multi-omics causal validation
In this study, researchers identified a causal link between Epstein-Barr virus infection and clear cell renal cell carcinoma, highlighting GBP1 as a key target and suggesting finasteride as a potential inhibitor, offering a new direction for treatment strategies.
research The Debt Financing of Parenthood
This review discusses the role of lenders in the parenthood market and financing options for assisted reproduction and adoption, presenting various legal and economic implications without reporting new research results.
research Reply to: The use of low-level light for hair growth: Part I
This article describes a non-blinded study investigating low level laser therapy for seven patients but reports no new clinical findings.
research Enhancing Hair Follicle Stimulation: A Nanoliposome-Based Delivery of Lavender Essential Oil (Lavandula angustifolia Mill.)
In this study, LEON gel—an innovative nanoliposome-based delivery system for lavender essential oil—showed significant hair growth acceleration in male white rats without causing irritation, suggesting enhanced effectiveness compared to traditional essential oil use.
research Developmental Toxicity of Levo-Alpha-Acetylmethadol (LAAM) in Tolerant Rats
In this study on tolerant rats, maternal and developmental toxicity from levo-alpha-acetyhnethadol hydrochloride were observed at all doses, without specific fetal toxicity or teratogenic effects.
research A CASE STUDY OF LEECH THERAPY (JALAUKAVCHARAN) IN KHALITYA W. S. R. ALOPECIA AREATA
This case study reports that a 30-year-old woman with persistent hair fall experienced marked improvement following leech therapy (Jalaukavacharana) performed according to classical Ayurvedic protocols.