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Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.

This case report describes a 23-year-old male patient with nail discoloration that may be associated with COVID-19, suggesting possible microvascular damage.

This report describes a case in which intramuscular cyanocobalamin treatment reversed skin and nail pigmentation changes and premature gray hair caused by vitamin B12 deficiency due to pernicious anemia.

This case report describes a patient with skin and nail hyperpigmentation and premature gray hair due to vitamin B12 deficiency, which were reversed after treatment with cyanocobalamin.

This article reviews various "white diseases" characterized by hypopigmentation or depigmentation and emphasizes the role of melanosomes in skin and eye color, but it does not present new clinical results.

HIV can cause various nail and hair disorders, important for early diagnosis and treatment.

This article discusses hair and nail research contributions in dermatology but reports no new clinical findings.

This article discusses two cases of follicular dyskeratosis (Darier-White disease), highlighting its rare occurrence, genetic basis, and the challenges in diagnosis and treatment; it presents no new experimental results.

This review explores the impact of COVID-19 on skin appendages beyond COVID-toes, highlighting hair and nail disorders in affected individuals, but provides no new clinical results.

This diagnostic discussion reports that diffuse alopecia areata was identified in a patient with diffuse hair loss, based on specific histopathological features observed in a biopsy.

This study observed that baricitinib treatment led to significant improvements in hair regrowth and quality of life scores in adults with severe alopecia areata over 24 weeks, with an acceptable safety profile as most adverse effects were transient.

This study found that while most mice lacking MK6a and MK6b genes died from tongue epithelium disintegration, about 25% survived and showed no hair or nail defects due to a newly discovered MK6hf gene.

People with certain allergic conditions or higher white blood cell counts have more severe hair loss, and treating hair and nail side effects early in melanoma therapy can improve quality of life.

This review discusses the causes of nail pitting in children and adolescents, noting that while most cases are idiopathic, significant associations exist with conditions like psoriasis, juvenile arthritis, and alopecia areata, among others.

This study identifies various nail changes in alopecia areata, which can affect quality of life, and suggests that while spontaneous improvement is possible, further research is needed to refine treatment strategies.

This review reports on the use of nails as an alternative biological matrix to hair for assessing long-term drug consumption, emphasizing that while there are clear differences between nail and hair samples, more standardized research is necessary for definitive conclusions.

This review discusses soy's potential benefits for skin, hair, and nails, noting that while skin and nail improvements are more pronounced, hair benefits are modest; it reports no new clinical results.

In this study, oral minoxidil treatment at 2.5 mg/day significantly increased nail growth speed by 50.7% and hair growth speed by 35.9% in healthy adult men, while also increasing heart rate but not affecting blood pressure.

This study observed that nearly 70% of children with treatment-resistant alopecia areata had nail involvement, and while this was associated with longer disease duration, it did not correlate with the severity of scalp hair loss.

This abstract describes various hair and nail changes associated with HIV infection, highlighting telogen effluvium and onychomycosis as common manifestations, while noting that treatment for onychomycosis does not differ between HIV-infected and non-infected individuals.

In this study, researchers identified the ventral matrix as the primary source of nail plate formation, while the dorsal portion is generated by the apical matrix.

In this study, a 90-day course of a plant-based supplement significantly improved hair density, skin hydration, and nail growth among participants with dermatological concerns, while also reducing hair fall and pigmentation, without adverse effects.

This study reported that patients with specific Foxn1 mutations exhibited severe T-cell lymphopenia without the hair and nail abnormalities usually associated with these mutations.

This review reports that oral collagen peptide supplements may improve skin elasticity, hydration, and wrinkle appearance while also supporting hair and nail health and wound healing, but emphasizes the need for longer, high-quality studies due to current research limitations and variability in findings.

This study reported an unusual case of nail matrix involvement and trachyonychia in a child with juvenile pityriasis rubra pilaris, showing significant improvement with topical therapy and oral biotin.

This expert consensus statement highlights that while targeted cancer therapies significantly improve patient survival, they often result in various skin toxicities, underscoring the need for early diagnosis, management, and multidisciplinary care to maintain patients' quality of life and ensure treatment continuity.

Certain micronutrients may improve hair and nail health, but more research is needed to confirm their benefits.

This review discusses recent advances in understanding the genetics of hair and nail disorders and reports no new clinical results.

Human nails contain both skin and hair keratins, each needing different extraction methods.

This review reports that nail changes such as onycholysis, thin nails, and brittleness are associated with thyroid disorders, highlighting their importance in the early diagnosis of these conditions.