Clinical Cases of Darier-White Follicular Dyskeratosis

    October 2022 in “ Medičnì perspektivi ”
    V.Yе. Tkach, M.S. Voloshynovych, S.M. Romanchuk, Galyna Girnyk, N. R. Matkovska, Nataliia Kozak
    Image of study
    TLDR Darier-White disease causes skin and nail issues, starts around age 20, worsens until 40-50, and has poor treatment options.
    Darier-White disease, a rare hereditary skin disorder caused by a mutation in the ATP2A2 gene, presents with follicular papules and nail abnormalities, affecting both genders equally but more severely in males. It typically manifests around age 20 and progresses until 40-50, then gradually diminishes. Clinical features include yellow-brown papules that merge into plaques, primarily on the limbs, trunk, and large folds, with 20-30% of cases also affecting the oral mucosa. Dermatoscopy reveals distinctive yellow-orange-brown lumps. The prognosis is poor, and treatment is largely ineffective. The article details two clinical cases of this disease.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 487 results

      community 24M still losing on Dut and Oral Min

      in Update  26 upvotes 2 months ago
      A 24-year-old male is losing hair despite using dutasteride and oral minoxidil, with no regrowth from April to October 2024. He is considering increasing his dosage and looking for cheaper prescriptions, while others recommend consulting a trichologist or trying different treatments.

      community Fighting Hair loss AND Grey Hair

      in Treatment  18 upvotes 2 years ago
      The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.

      community Does finasteride/dutasteride reverse aging?

      in Chat  45 upvotes 2 months ago
      Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

      community Minoxidil seems logistically impossible and impractical to use

      in Minoxidil  136 upvotes 1 year ago
      The post discusses concerns about the practicality of using Minoxidil foam for hair loss, including the frequency of application, preparation, coverage area, and drying time. Responses suggest that missing a dose isn't detrimental, it can be applied once a day, it works on all hair areas, and it doesn't need to be perfectly dry before application.

    Similar Research

    5 / 1000+ results