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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The Rotterdam Study aims to understand various diseases in older adults.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Men with coeliac disease may have hormone imbalances that could affect sexual function, but these can improve with better gut health.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Some systemic treatments work for nail psoriasis but can have serious side effects.

Different treatments for alopecia areata have varying success rates and side effects; intralesional steroids are most effective.

Finasteride effectively reduces hair growth in women with polycystic ovary syndrome or idiopathic hirsutism.

Regenerative therapies show promise for treating vitiligo and alopecia areata.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Hair restoration surgery techniques have evolved, with focus on patient selection and realistic goals, and future advancements may include cloning and gene therapy.

The document concludes that quick referral and appropriate treatments are crucial for managing common skin conditions and preventing permanent damage.

International medical graduates outperformed U.S. graduates on an internal medicine exam.

A young woman had a rare skin reaction to a medication for her joint disease, and a combination therapy improved her condition.

A hormone linked to collagen helps hair grow back in mice after chemotherapy, and may also prevent bone loss.

Skin health and diseases are closely linked to metabolic processes.

Calcipotriol treatment for scalp psoriasis does not cause hair loss.

Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.

Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

Microneedle patches improve drug delivery for skin treatments and cosmetic enhancements.

The document gives treatment advice for various skin conditions, like using metronidazole for perioral dermatitis and minoxidil for hair loss.

Taking high doses of fluconazole for a long time can cause reversible hair loss.

Natural products like propolis are causing more skin allergies, and certain skin treatments and medications have various side effects and risks.

Male pattern hair loss may have evolved to promote younger fathers for offspring health and survival, encouraging monogamy and paternal nurturing.

Biotinidase deficiency has various symptoms and can be treated with biotin supplements.