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This article analyzes the potential for insights from monogenic disorders to inform the understanding and treatment of common polygenic diseases, though complete predictability based on genotype remains unrealistic.

This review analyzed observational studies on endogenous sex steroids and CVD risk, reporting mixed findings: lower testosterone and higher estradiol levels were associated with increased CVD risk, but significant literature gaps remain.

This article reviews how skin manifestations can aid in diagnosing various systemic diseases, focusing primarily on their association with rheumatologic conditions while also addressing vascular, granulomatous, and other disease impacts, aiming to provide dermatologists with practical diagnostic insights.

This article reviews androgen excess and cardiometabolic risks in women, highlighting increased cardiovascular disease risk in those with polycystic ovary syndrome, but reports no new clinical results.

In this case report, a 25-year-old woman with VKHD experienced an unusual occurrence of vellus-like hair growth on her normally hairless palm, observed twice over two years, expanding the known integumentary manifestations of VKHD.

This study found that specific dermoscopic signs, such as diameter diversity of leukotrichia and Pohl-Pinkus constrictions, were associated with progressive vitiligo, and early-stage melanin synthesis was impaired in vitiligo-associated leukotrichia.

In this case report, a 46-year-old woman initially diagnosed with 21-hydroxylase deficiency congenital adrenal hyperplasia was later identified as having 3β-HSD2 deficiency after further investigation, highlighting the need for awareness of rarer CAH forms to prevent delayed diagnosis and insufficient treatment.

In this study, a Chinese Han family with hereditary vitamin D-resistant rickets was found to have a homozygous missense mutation in the VDR gene, and the affected individual uniquely responded well to treatment with oral calcium and low-dose calcitriol.

This report highlights a case where intralesional cidofovir successfully treated squamous cell carcinoma without systemic toxicity, suggesting it may be a viable alternative to surgical excision.

This study found that individuals with heterozygous truncation-type variants in the *DSP* gene exhibit lower skin temperature and higher transepidermal water loss, with specific microscopic skin changes and pseudomonilethrix.

In this study, eight patients with hereditary vitamin D-resistant rickets who share a specific VDR mutation showed improved clinical symptoms except alopecia after up to 11 years of treatment.

This review discusses genetic mutations associated with Hutchinson-Gilford progeria syndrome and reports no clinical results; the authors emphasize the importance of cardiovascular monitoring in management.

Early male hair loss might signal higher heart disease risk.

This study examined medical comorbidities and medications among women with vulvar lichen sclerosus, contributing insights for comprehensive treatment strategies, but does not report new clinical results.

This review discusses various adverse skin reactions linked to cardiovascular medications and reports no new clinical results, highlighting the need for vigilance when prescribing these drugs.

This study found that off-pump coronary surgery significantly reduces in-hospital morbidity compared to on-pump surgery without affecting midterm outcomes in the first 1-3 years after the procedure.

This study found that echogenic liposomes improved the delivery and penetration of CRISPR/Cas9 genetic materials into cardiomyocytes, both in vitro and in vivo, especially when combined with ultrasound, highlighting a promising strategy for cardiovascular gene therapy.

This study found that among older men, lower calculated free testosterone was significantly associated with a higher risk of heart failure, suggesting a possible role of testosterone deficiency in heart failure incidence.

This case report highlights that diffuse alveolar hemorrhage is a rare but severe complication of systemic lupus erythematosus, posing diagnostic challenges and necessitating urgent treatment to potentially improve patient outcomes.

Androgenetic alopecia is not linked to higher heart disease risk.

This case report highlights a rare instance of costovertebral arthritis secondary to Systemic Lupus Erythematosus, emphasizing the importance of detailed clinical evaluation and imaging for accurate diagnosis and management of chronic back and chest pain.

In this case report, a 59-year-old man experienced recurrent pericardial effusion linked to minoxidil, with serologic indications of drug-induced lupus erythematosus, underscoring the need for clinicians to consider this rare complication of widespread minoxidil use.

Adding diltiazem to a beta blocker can cause dangerously slow heart rates.

Oral propranolol successfully treated a baby's skin growth and ulceration linked to PELVIS syndrome.

More research is needed to understand sex and racial differences in long COVID.

This study found that anabolic steroid use combined with plakoglobin deficiency caused pathological atrial electrical remodeling in young male mice, suggesting a higher risk of atrial myopathy for males with desmosomal gene variants.

This study found that prenatal exposure to androgens caused long-lasting heart remodeling and left ventricular hypertrophy in female mice offspring, suggesting potential cardiac risks for daughters of mothers with PCOS.

This abstract provides a narrative overview of polycystic ovary syndrome, discussing its symptoms and related health issues, and does not include new research findings.