A Fatal Case of Systemic Lupus Erythematosus Complicated with Diffuse Alveolar Hemorrhage

January 2021 in “ International Journal of Immunology ”

Parackrama Karunathilake, Ruwanthi Jayasinghe, Thilak Jayalath, Shamali Abeyagunawardena, Udaya Ralapanawa

alopecia systemic lupus erythematosus SLE lupus nephritis methylprednisolone plasmapheresis hair loss lupus steroids

TLDR Early detection and aggressive treatment of severe lung complications in lupus are crucial to improve survival.

A 31-year-old female with systemic lupus erythematosus (SLE) presented with symptoms including alopecia, anorexia, and weight loss, and was diagnosed with class 3 lupus nephritis. She later developed diffuse alveolar hemorrhage (DAH), a rare and severe complication of SLE, leading to acute respiratory distress and hemodynamic instability. Despite intensive treatment including antibiotics, methylprednisolone, plasmapheresis, and continuous renal replacement therapy (CRRT), her condition deteriorated, resulting in cardiac arrest and death. The case highlighted the critical need for early detection and aggressive management of DAH in SLE patients to improve outcomes.

View this study on article.sciencepublishinggroup.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

in Treatment 6 upvotes 4 years ago

Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

in Chat 15 upvotes 8 months ago

A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

in Research/Science 243 upvotes 2 months ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 88 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community If follicles became miniaturized and haven’t grown in 3 years, are they dead ?

in Chat 2 years ago

Hair loss and its potential treatments, such as minoxidil, finasteride, RU58841, dermarolling, and supplements. It discusses whether miniaturized follicles can be revived to grow again or must shed for new growth to appear.

Similar Research

6 / 1000+ results

An Atypical Initial Manifestation of Systemic Lupus Erythematosus: Lupus Enteritis Accompanied by Intestinal Pseudo-Obstruction and Bilateral Hydronephroureter

research An Atypical Initial Manifestation of Systemic Lupus Erythematosus: Lupus Enteritis Accompanied by Intestinal Pseudo-Obstruction and Bilateral Hydronephroureter

December 2023 in “Curēus”

A woman with lupus had rare severe symptoms but improved with treatment.

$Case Report: Reversal of Long-Standing Refractory Diffuse Non-Scarring Alopecia Due to Systemic Lupus Erythematosus Following Treatment With Tofacitinib$

research Case Report: Reversal of Long-Standing Refractory Diffuse Non-Scarring Alopecia Due to Systemic Lupus Erythematosus Following Treatment With Tofacitinib

6 citations, April 2021 in “Frontiers in Immunology”

A patient with lupus and long-term hair loss saw significant hair regrowth after using the drug tofacitinib.

research Cutaneous Lupus Erythematosus: Diagnostic and Therapeutic Recommendations of the Polish Dermatological Society

January 2018 in “Przegla̧d dermatologiczny”

The Polish Dermatological Society recommends personalized treatment for cutaneous lupus, including lifestyle changes, medications, and monitoring, with specific drugs for severe cases.

research Covid-19 in Lupus Nephritis

April 2021 in “Bioscientia Medicina Journal of Biomedicine and Translational Research”

Patients with lupus nephritis and COVID-19 can improve with proper treatment.

research Covid-19 in Lupus Nephritis

April 2021 in “Bioscientia Medicina Journal of Biomedicine and Translational Research”

Hydroxychloroquine may help COVID-19 patients with lupus.

research Flares of Systemic Lupus Erythematosus During Pregnancy and the Puerperium: Prevention, Diagnosis, and Management

87 citations, July 2012 in “Expert Review of Clinical Immunology”

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.