Male Sex Hormone and Reduced Plakoglobin Jointly Impair Atrial Conduction and Cardiac Sodium Currents
June 2022
in “
bioRxiv (Cold Spring Harbor Laboratory)
”
androgenic anabolic steroids plakoglobin atrial conduction cardiac sodium currents arrhythmogenic right ventricular cardiomyopathy 5α-dihydrotestosterone DHT pro-hypertrophic transcripts fibrotic transcripts inflammatory transcripts sodium current density action potential amplitude Na v 1.5 clustering atrial electrical remodeling atrial myopathy desmosomal gene variants AAS
Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.
Studysummary This study found that anabolic steroid use combined with plakoglobin deficiency caused pathological atrial electrical remodeling in young male mice, suggesting a higher risk of atrial myopathy for males with desmosomal gene variants.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
Read the full study on biorxiv.org →