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research Male sex hormone and reduced plakoglobin jointly impair atrial conduction and cardiac sodium currents

June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that anabolic steroid use combined with plakoglobin deficiency caused pathological atrial electrical remodeling in young male mice, suggesting a higher risk of atrial myopathy for males with desmosomal gene variants.

Correlation of Monosynaptic Field Potentials Evoked by Single Action Potentials in Single Primary Afferent Axons and Their Bouton Distributions in the Dorsal Horn

research Correlation of monosynaptic field potentials evoked by single action potentials in single primary afferent axons and their bouton distributions in the dorsal horn

21 citations , April 1990 in “Journal of comparative neurology”

This study found that the spinal projection of afferents innervating slowly adapting mechanoreceptors had a greater rostrocaudal extent and number of boutons compared to those innervating rapidly adapting mechanoreceptors.

Androgenic Effects on Ventricular Repolarization: A Translational Study from Pharmacovigilance Databases to iPSC-Cardiomyocytes

research P6590Androgenic effects on ventricular repolarization: a translational study from pharmacovigilance databases to iPSC-cardiomyocytes

October 2019 in “European heart journal”

This study found that androgen deprivation therapy is associated with an increased risk of acquired long-QT syndrome and Torsades de Pointes, particularly highlighting enzalutamide's greater association with sudden death compared to other therapies.

research Hormonal Control of Cardiac Action Potential Phase 1 Currents in the Brugada Syndrome

February 2014 in “Revista Argentina de Cardiología”

In this study, testosterone was found to increase the risk of arrhythmias in a rat heart model, while finasteride reduced this arrhythmogenic effect.

research Prooxidant and antioxidant action of 4-(4-phenoxybenzoyl)benzoic acid derivatives

2 citations , February 2004 in “Biopolymers”

This study found that 4-(4-Phenoxybenzoyl)benzoic acid derivatives may act as antioxidants by scavenging certain reactive oxygen species but exhibit prooxidant behavior under specific conditions.

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Community Join

5 / 737 results

community Keep your heads up bros, don't let balding affect your mental

64 upvotes 7 months ago

Hair loss can cause psychological distress, but maintaining optimism and self-improvement is crucial. Treatments like minoxidil, finasteride, and potential new options like clascoterone offer hope, though side effects can occur.

community Finasteride success for androgenic alopecia by a 27M physician (NO PICTURES)

4 upvotes 10 years ago

A 27-year-old male physician improved hair density using minoxidil 5% foam and finasteride 1mg every other day, with initial sexual side effects that subsided. He recommends trying finasteride for a year but warns against dutasteride due to potential liver effects.

community “Is France going to veto the EU and ban finasteride and dutasteride?”

in Finasteride/Dutasteride 26 upvotes 1 year ago

Concerns about France potentially banning finasteride and dutasteride due to supposed side effects, though no solid evidence supports this action. Users believe a ban is unlikely and discuss ways to obtain the treatments if it occurs.

community Pelage Pharmaceuticals with an absolute stunner of a molecule

in Chat 4 months ago

PP405 is a promising new treatment for hair loss. It performs three actions in one, potentially offering a cure.

community Pelage Recruiting Now for Phase 2

11 upvotes 2 years ago

Pelage is recruiting for phase 2 trials, showing promise for treating bald regions. The discussion highlights its potential effectiveness based on its mechanism of action.

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Learn

1 / 801 results

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

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Clinics

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