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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Long-term finasteride use doesn't change bone density or metabolism.

Taking 5α-reductase inhibitors does not significantly increase the risk of breast cancer in men.

Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.

Dutasteride does not impair mental function in elderly men with enlarged prostate.

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

Minoxidil lowers blood pressure and increases heart efficiency, but may raise lung artery pressure in some people.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Biotin supplements improved skin and hair problems in a girl with biotinidase deficiency.

People with Mucopolysaccharidoses often have skin problems like thick skin and extra hair, and recognizing these can help diagnose and treat the condition early.

The review concludes that the Ziziphus species, especially jujube, may promote hair growth and have various health benefits, warranting more research.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Green algae can break down finasteride, reducing environmental harm.

The document concludes that secondary syphilis cases are increasing and often misdiagnosed, pityriasis rubra pilaris can be distinguished from psoriasis by skin cell features, and different skin layers produce specific components during skin repair.

The document concludes that finasteride can reduce nandrolone detection in doping tests, suggesting frequent testing and setting metabolite level thresholds for detection.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Finasteride improves chronic pelvic pain, saw palmetto doesn't.

Olive oil compounds may help prevent cancer in animals, but human results are mixed.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Some drugs may reduce prostatitis symptoms short-term with few side effects.

Minoxidil effectively controls blood pressure in severe cases, but may cause fluid retention and edema.

Androgens significantly affect female hair loss, and hormonal treatments may help.