This study found that Nubian ibex have developed genetic adaptations in response to their desert environment, including enhanced skin barrier, DNA repair, viral response, and metabolism of toxic compounds.
1 citations
,
January 2014 in “Hair therapy & transplantation” This review discusses various treatment options for Alopecia Areata, focusing on both medical and psychological approaches, and reports no new clinical results.
99 citations
,
July 2017 in “Clinical Reviews in Allergy & Immunology” This review noted that alopecia areata is an autoimmune disease impacting hair follicles and offered insights into its complex pathogenesis involving immune responses, while highlighting ongoing research into new treatments such as Janus kinase inhibitors and other immunomodulatory drugs.
70 citations
,
February 2015 in “Expert Opinion on Drug Discovery” This review discusses current knowledge on the biological mechanisms of different types of alopecia but reports no new clinical findings; the authors highlight future research directions, especially regarding epidermal stem cells and immune pathways.
39 citations
,
April 2016 in “Case Reports in Dermatology” This study observed initial hair regrowth in a businessman with alopecia areata universalis treated with tofacitinib, but the effect diminished, leading to renewed hair loss.
January 2018 in “Elsevier eBooks” This chapter reviews various in vitro and laboratory animal models for studying potential therapies for alopecia and reports no new results.
80 citations
,
April 2018 in “Trends in Molecular Medicine” This review discusses the roles of interferon-γ and PPAR-γ-mediated signalling in scarring alopecia, suggesting these pathways as potential therapeutic targets, but it reports no new empirical results.
421 citations
,
April 2012 in “The New England Journal of Medicine” Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.
In this study, researchers found that alopecia areata is linked to immune cell activation against hair follicle autoantigens and is associated with heart changes and cardiac marker alterations in humans and mice.
14 citations
,
March 2022 in “Journal of inflammation research” This review discusses the application and potential of baricitinib, a JAK1/2 inhibitor, for treating dermatological diseases like alopecia areata and reports no new clinical results.
11 citations
,
November 2012 in “Seminars in Cutaneous Medicine and Surgery” This review summarizes current understanding and genetic insights into androgenetic alopecia, female pattern hair loss, and alopecia areata, noting the potential future role of molecular diagnostics, but it reports no new clinical results.
4 citations
,
November 2023 in “Frontiers in immunology” In this narrative review, researchers outlined the role of T cells in the autoimmune pathogenesis of alopecia areata and highlighted ongoing research into therapeutic pathways, beyond current JAK inhibitors, aimed at developing new treatments for the disease.
4 citations
,
January 2021 in “Skin appendage disorders” This review discusses the complex causes of trichodynia and reports no clinical results; the authors call for more research into neural and immune interactions in scalp conditions.
January 2025 in “Universidad de Córdoba Insitutional Repository (Universidad de Córdoba)” In this study, researchers observed that individuals with alopecia areata exhibited significant changes in scalp microbiota diversity and composition, which were linked to disease severity and inflammation markers, though it remains unclear if these microbial shifts are a cause or a result of hair loss.
January 2012 in “Elsevier eBooks” This chapter reviews therapies for skin and corneal regeneration and hair loss, discussing various treatments but presenting no new research findings.
144 citations
,
July 2015 in “Clinical, Cosmetic and Investigational Dermatology” This review reports that alopecia areata affects about 2% of people globally and is linked with psychiatric and medical comorbidities, highlighting its significant disease burden.
290 citations
,
December 2017 in “Journal of The American Academy of Dermatology” This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.
53 citations
,
March 2014 in “Cold Spring Harbor Perspectives in Medicine” The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.
13 citations
,
May 2023 in “Journal of Dermatological Science” This research found that reduced expression of SIRT1 in human scalp tissue may contribute to alopecia areata development by inducing immune-inflammatory responses in hair follicle cells, suggesting that SIRT1 plays a regulatory role in hair follicle immunity.
7 citations
,
November 2018 in “British Journal of Dermatology” Alopecia areata is caused by immune system issues, and JAK inhibitors might help treat it.
7 citations
,
July 2024 in “Frontiers in Immunology” This article reviews current research on the link between COVID-19 and alopecia areata, suggesting COVID-19 may increase the risk of autoimmune diseases, including alopecia, especially in those over 40, and discusses potential mechanisms and treatment options.
5 citations
,
October 2021 in “Clinical, cosmetic and investigational dermatology” In this study, Japanese patients with alopecia areata were found to have higher BMI and retinol intake, with retinol intake predicting severity of hair loss.
January 2020 in “Archives of Medicine and Health Sciences” This review discusses potential biomarkers for alopecia and their significance, and while it highlights areas for future research, it reports no new clinical results.
1 citations
,
September 2024 in “Life” This study reports three cases of alopecia areata resistant to corticosteroids that improved after 16 weeks of treatment with a combination of fractional carbon dioxide laser and topical tacrolimus, suggesting a potential new therapeutic option that requires further confirmation.
91 citations
,
January 2010 in “Journal of Allergy and Clinical Immunology” This review explores the emerging roles of NK cells in various diseases, including allergies and skin conditions, and reports no new clinical results while indicating NK cell involvement in immune processes.
40 citations
,
October 2012 in “Dermatologic clinics” This review highlights the need for a deeper understanding of the genetic mechanisms in alopecia areata to develop evidence-based treatments, but it provides no new experimental results.
March 2022 in “Wound practice & research” This review synthesizes current evidence on alopecia areata, detailing its clinical features, pathogenesis, and treatment options, but does not present new clinical results.
253 citations
,
December 2007 in “Journal of Investigative Dermatology” This study suggests that human hair follicles may actively suppress natural killer cells, which contrasts with the observed defects in NK cell regulation in alopecia areata.
134 citations
,
July 2020 in “Experimental dermatology” This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.
61 citations
,
September 2010 in “Journal of Dermatological Science” This review discusses the interplay between hormonal and immune systems in hair follicles and reports no new results, highlighting the need for further research on their role in skin biology and alopecia areata.