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    Glossary Tyrosine Kinase

    enzyme that transfers phosphate groups to tyrosine on proteins

    Tyrosine Kinase (TK) is an enzyme that functions by transferring a phosphate group from ATP to a specific amino acid called tyrosine on a protein. This process, known as phosphorylation, is crucial for regulating various cellular activities, including cell division, growth, and signaling pathways. Dysregulation of tyrosine kinases can lead to diseases such as cancer, making them important targets for certain therapeutic drugs.

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    Research 30 of 1000+

    1. Repigmentation of leukoderma in a piebald patient associated with a novel c-KIT gene mutation, G592E, of the tyrosine kinase domain Journal of Dermatological Science · 2011 · 6 citations
    2. Clinical Manifestations of Hyperandrogenism and Ovulatory Dysfunction Are Not Associated with His1058 C/T SNP (rs1799817) Polymorphism of Insulin Receptor Gene Tyrosine Kinase Domain in Kashmiri Women with PCOS International Journal of Endocrinology · 2021 · 6 citations
    3. 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis Journal of Investigative Dermatology · 2017
    4. Epidermal growth factor receptor mutant T790M-L858R-V948R inhibitor from Calophyllum inophyllum L. leaf as potential non-small cell lung cancer drugs Journal of pharmacy & pharmacognosy research · 2024
    5. Trichomegaly of the Eyelashes After Treatment with Erlotinib in Non-small Cell Lung Cancer Journal of thoracic oncology · 2006 · 12 citations
    6. A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib JAMA Dermatology · 2013 · 16 citations
    7. Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System Scientific Reports · 2020 · 58 citations
    8. 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model Journal of Investigative Dermatology · 2022
    9. Keratosis Pilaris-like Eruption during Treatment of Chronic Myeloid Leukemia with Tyrosine Kinase Inhibitors: Literature Review and Report of a Case Related to Imatinib Journal of clinical medicine · 2023
    10. Characterisation, genomic organisation, expression and function of the mEphA1 receptor Tyrosine Kinase 2007
    11. Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases Frontiers in immunology · 2019 · 88 citations
    12. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004 · 11 citations
    13. Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies Biomedicines · 2025
    14. Tyrosine Kinase Inhibitors against Cancer: Their Safety in 216 Moroccan Patients Journal of Cancer Therapy · 2021
    15. Receptor tyrosine kinase Kit action in skin melanocytes: is it exclusively cell autonomous? Experimental Dermatology · 2015 · 1 citations
    16. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    17. The PDGF/PDGFR pathway as a drug target Molecular Aspects of Medicine · 2017 · 182 citations
    18. Dasatinib-Induced Leukotrichia in a Patient With Chronic Myelogenous Leukemia JAMA Dermatology · 2013 · 9 citations
    19. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer Journal of the American Academy of Dermatology · 2014 · 88 citations
    20. Activity of Sorafenib against Desmoid Tumor/Deep Fibromatosis Clinical Cancer Research · 2011 · 215 citations
    21. MicroRNA control of signal transduction Nature Reviews Molecular Cell Biology · 2010 · 1066 citations
    22. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    23. Nilotinib-induced generalized keratosis pilaris: Report of a rare case Indian Journal of Pharmacology · 2021 · 5 citations
    24. Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress International journal of biological sciences · 2023 · 2 citations
    25. “<i>Nomen Omen</i>: The Myth of God Janus” JEADV Clinical Practice · 2025
    26. Erlotinib-Associated Alopecia in a Lung Cancer Patient Journal of Thoracic Oncology · 2007 · 8 citations
    27. The Dark Side of Gefitinib: Reflectance Confocal Microscopy Applied to Hair Hyperpigmentation Skin Appendage Disorders · 2019 · 4 citations
    28. Drug-induced hair pigmentation: Clinical perspectives and updates JAAD reviews. · 2024 · 2 citations
    29. Drug-induced scarring and permanent alopecia JAAD reviews. · 2024 · 2 citations
    30. Efficacy and Tolerability of Brevilin-A, a Natural JAK Inhibitor, in Pediatric Alopecia Areata: A Case Series Clinical Cosmetic and Investigational Dermatology · 2024