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    Did you mean Tyrosine Kinase Inhibitors?
    Glossary Tyrosine Kinase Inhibitors

    block enzymes that regulate cell growth and division

    Tyrosine Kinase Inhibitors (TKIs) are a class of medications that block the action of enzymes called tyrosine kinases, which are involved in the signaling pathways that regulate cell division and survival. By inhibiting these enzymes, TKIs can help to slow down or stop the growth of cancer cells, making them a valuable treatment option for certain types of cancer.

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    Research 30 of 1000+

    1. Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in patients with alopecia areata: efficacy and safety results of a phase II, multicenter, randomized, double-blinded, placebo-controlled trial British Journal of Dermatology · 2026
    2. 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis Journal of Investigative Dermatology · 2024 · 1 citations
    3. 27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management 2023
    4. 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model Journal of Investigative Dermatology · 2022
    5. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    6. 061 Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12-induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy? Journal of Investigative Dermatology · 2021
    7. Epidermal growth factor receptor mutant T790M-L858R-V948R inhibitor from Calophyllum inophyllum L. leaf as potential non-small cell lung cancer drugs Journal of pharmacy & pharmacognosy research · 2024
    8. 014 Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model 2022
    9. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    10. Safety of Tyrosine Kinase Inhibitors in Patients With Differentiated Thyroid Cancer: Real-World Use of Lenvatinib and Sorafenib in Korea Frontiers in Endocrinology · 2019 · 39 citations
    11. Comparison of pemetrexed and docetaxel as salvage chemotherapy for the treatment for nonsmall-cell lung cancer after the failure of epidermal growth factor receptor-tyrosine kinase inhibitors Journal of international medical research · 2014 · 12 citations
    12. Treatment of discoid lupus erythematosus scarring alopecia with deucravacitinib: A case report SAGE Open Medical Case Reports · 2025 · 3 citations
    13. Hair regrowth in a patient with alopecia universalis and psoriasis vulgaris during deucravacitinib therapy JDDG Journal der Deutschen Dermatologischen Gesellschaft · 2024
    14. Skin Biology and Ageing Skin Health and Disease · 2023
    15. Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne 2009 · 65 citations
    16. Severe scarring alopecia associated with combinational use of ficlatuzumab and gefitinib: a clinical and immunohistochemistry study Journal of dermatological science · 2012 · 1 citations
    17. Phase I safety and pharmacokinetic study of SU-014813 in combination with docetaxel in patients with advanced solid tumours European Journal of Cancer · 2011 · 22 citations
    18. Erlotinib-Associated Alopecia in a Lung Cancer Patient Journal of Thoracic Oncology · 2007 · 8 citations
    19. Unexpected hair growth induced by gefitinib treatment in two patients with EGFR gene mutation-positive adenocarcinoma of the lung 2015 · 1 citations
    20. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer Journal of the American Academy of Dermatology · 2014 · 88 citations
    21. A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib JAMA Dermatology · 2013 · 16 citations
    22. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    23. Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System Scientific Reports · 2020 · 58 citations
    24. Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies Biomedicines · 2025
    25. Keratosis Pilaris-like Eruption during Treatment of Chronic Myeloid Leukemia with Tyrosine Kinase Inhibitors: Literature Review and Report of a Case Related to Imatinib Journal of clinical medicine · 2023
    26. Tyrosine kinase Inhibitors in Dermatology: A Systemic Review Journal of dermatology and dermatitis · 2021 · 1 citations
    27. Tyrosine Kinase Inhibitors against Cancer: Their Safety in 216 Moroccan Patients Journal of Cancer Therapy · 2021
    28. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    29. Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities Journal of the Formosan Medical Association · 2017 · 22 citations
    30. Tyrosine kinase inhibition and grey hair The Lancet · 2003 · 59 citations