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European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Some systemic treatments work for nail psoriasis but can have serious side effects.

Cancer development is like natural selection, involving mutated cells and environmental factors.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Both mouse and rat models are effective for testing alopecia areata treatments.

Alopecia areata involves immune system imbalances that may lead to depression and anxiety.

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

Men are more likely to get infectious skin diseases, while women are more prone to autoimmune and pigment-related skin conditions, influenced by biological and environmental factors.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.

COVID-19 might affect male fertility, but more research is needed to understand the full impact.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

CYLD mutations cause a variety of skin tumors with symptoms starting around age 16, and treatments are currently limited.

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

Children generally have milder SARS symptoms than adults, with good outcomes and no deaths reported, but long-term effects are unclear.

Scalp cooling can help prevent chemotherapy-induced hair loss with a 50-90% success rate and is safe for patients.

Adrenal disorders can cause lasting brain and behavior issues in children.

Prostaglandin E2 affects human platelet activity in complex ways that could lead to personalized heart disease treatments.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

Baldness at age 40 is not linked to a higher risk of aggressive prostate cancer.

Certain microRNAs are linked to various skin diseases and could be used to diagnose and treat these conditions.