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Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

Fat cells in the skin help start healing and form important repair cells after injury.

Women with PCOS and higher androgen levels are more likely to have fatty liver disease.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

South Asian women with PCOS are more likely to have metabolic issues and central obesity, and simple measures like waist size and blood pressure can help identify these risks early.

Hair loss linked to higher heart disease risk in both men and women.

The Protein-Sparing Modified Fast is effective for rapid weight loss and maintaining it, but requires medical supervision and can have side effects.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Skin fat helps with body temperature control and has other active roles in health.

The conclusion is that early diagnosis and a multi-system treatment approach are crucial for managing PCOS and its associated health risks.

Smoking linked to hair loss in Asian men.

Metformin improves hair growth and menstrual frequency in women with PCOS and hirsutism.

Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Gynecologists should provide comprehensive care for transgender patients, including mental health evaluation, hormone therapy, and surgical options, while monitoring for side effects and ensuring patient safety.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

HFMs can help study hair growth and test potential hair growth drugs.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

The intensive conventional diet with exercise led to better long-term weight loss and health improvements than the very low calorie diet in obese type 2 diabetics.