4 citations
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January 2021 in “Skin appendage disorders” This review discusses the complex causes of trichodynia and reports no clinical results; the authors call for more research into neural and immune interactions in scalp conditions.
3 citations
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September 2018 in “Journal of Structural Biology” Oxidized trichocyte keratin has a helical dislocation in its structure.
1 citations
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January 2021 in “Springer Proceedings in Materials” This study demonstrates a sample preparation method for wool follicles that allows for clear keratin labeling and ultrastructural preservation in microscopy, reducing common artefacts from conventional fixation techniques.
June 2026 in “Dermatology and Therapy” In this retrospective analysis, patients with trichodynia who were unresponsive to standard treatments showed significant symptom improvement after receiving intradermal botulinum toxin type A, with nearly all patients benefiting, particularly those with scarring alopecia.
July 2025 in “ALEXMED ePosters” In this study, the researchers aimed to evaluate the levels of substance P, folic acid, and ferritin in the serum of female patients experiencing hair fall and trichodynia.
March 2025 in “International Journal of Trichology” This study describes a 62-year-old male with trichodaganomania, an urge to bite his mustache hair, who was treated with counseling and placebo medication, highlighting the need for a comprehensive treatment approach including potential psychological and psychiatric interventions if symptoms recur.
January 2025 in “Journal of the Egyptian Womenʼs Dermatologic Society” This study found that patients with trichodynia associated with androgenetic alopecia had significantly higher levels of substance P in both tissue and serum compared to healthy controls, suggesting a potential role for this neurotransmitter in the condition's pathogenesis.
In this case report, off-label onabotulinumtoxin-A was successfully used to treat trichodynia, a painful scalp sensation associated with hair loss, in a patient unresponsive to conventional therapies.
This study observed that post-COVID patients, especially females, commonly experience Telogen Effluvium, with earlier onset and increased trichodynia in those with more severe COVID-19.
January 2022 in “Journal of Skin and Stem Cell” This review discusses trichodynia, its potential causes, and treatment options, but reports no new clinical findings.
April 2017 in “InTech eBooks” This review discusses potential mechanisms and treatments for trichodynia, noting a lack of strong literature support and reporting no new clinical results; the authors highlight several hypotheses and available treatment options.
January 2016 in “International Journal of Medical Research and Health Sciences” This study found that trichodynia was significantly more common in patients with Telogen Effluvium and Alopecia Areata, and anxiety frequently accompanied trichodynia in these conditions.
March 2012 in “Journal of The American Academy of Dermatology” Higher levels of certain nerve-related proteins are linked to hair loss in women with scalp pain.
13 citations
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January 2018 in “Advances in experimental medicine and biology” 7 citations
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January 2017 in “Sub-cellular biochemistry/Subcellular biochemistry”
7 citations
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January 1998 in “PubMed” Hair loss can cause scalp discomfort.
43 citations
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April 1996 in “Journal of Investigative Dermatology”
13 citations
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July 2017 in “Biopolymers” This study presents recombinant human hair keratins K31 and K81, observing novel nanostructures from their self-assembly and emphasizing disulfide crosslinking's role in this process.
January 1993 in “Nihon Chikusan Gakkaiho” This research found that a monoclonal antibody (MAb 17) specifically reacts with certain subunits of trichocyte keratin in rats, and discovered that trichocyte keratin expression in hair and whiskers begins at different embryonic stages.
5 citations
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September 2013 132 citations
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February 2002 in “Journal of Biological Chemistry” This study demonstrated that HOXC13 directly influences hair keratin gene expression by binding to specific DNA motifs, suggesting its role in early hair follicle differentiation.
80 citations
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March 2008 in “Contact Dermatitis” This study found that scalp sensitivity frequently occurs in the French population and is associated with various symptoms and triggers, differing from facial skin sensitivity.
79 citations
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March 2005 in “Journal of Medical Genetics” This study identified a novel heterozygous missense mutation in the hHb3 gene associated with monilethrix, highlighting its role in this hair disorder.
62 citations
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January 2000 in “Developmental dynamics” This study found that Notch-related genes, including Notch1 and Notch2, and their ligands and regulators, have distinct patterns of expression during mouse hair vibrissa follicle development and the adult hair cycle.
56 citations
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August 2019 in “Clinical, Cosmetic and Investigational Dermatology” This essay discusses telogen effluvium, the issues surrounding its diagnosis and differentiation from other forms of hair loss, and emphasizes the need for empathetic patient care; it reports no new clinical findings.
46 citations
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June 2013 in “Journal of structural biology” This study suggests that the mechanical robustness of hair may be enhanced by the binding interactions of keratin-associated proteins, particularly KAP8.1, with intermediate filament proteins.
45 citations
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January 2015 in “Dermatology” In this study, 41.6% of patients with secondary syphilis exhibited syphilitic alopecia, with the 'moth-eaten' pattern most commonly observed through trichoscopy.
39 citations
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June 2012 in “Journal of Structural Biology” Disulfide bonds are crucial for hair structure during keratinization.
32 citations
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October 2009 in “Dermatology” This article describes acute and chronic telogen effluvium, highlighting the importance of differentiating them from androgenetic alopecia for accurate diagnosis and treatment strategies but includes no new clinical research findings.
30 citations
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October 1994 in “Journal of Cutaneous Pathology” This article describes a case of multiple perifollicular fibromas and suggests that cases previously reported as such might actually be instances of Birt‐Hogg‐Dubé syndrome.