10 citations
,
July 1980 in “British Journal of Dermatology” This study observed that applying polyamines to the skin of hairless mice stimulates thymidine incorporation, suggesting polyamines may play a role in DNA synthesis control in the epidermis.
63 citations
,
September 1987 in “Journal of Biological Chemistry” Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.
January 1998 in “Proceedings of the British Society of Animal Science” This study investigated the effects of biotin deficiency and adequacy on cell proliferation and DNA synthesis in isolated mohair follicles, particularly focusing on the incorporation of [methyl-3 H]thymidine.
January 1998 in “Proceedings of the British Society of Animal Science” This study examined the role of biotin deficiency and adequacy on cell proliferation and DNA synthesis in isolated mohair follicles.
28 citations
,
January 2003 in “Skin pharmacology and physiology” This study found that melatonin's effect on HaCaT keratinocyte proliferation varied with concentration and incubation time, with no cytotoxic effects observed at suitable concentrations for skin treatment.
54 citations
,
July 1967 in “Science” This study found that aged tritiated thymidine breaks down and incorporates into cytoplasmic macromolecules, not DNA, suggesting caution in its use.
38 citations
,
April 2016 in “Experimental Dermatology” This review discusses immunohistological and immunofluorescent methods for studying the human hair follicle cell cycle, reporting no new results, and suggests its potential for advancing cell cycle research.
November 2020 in “Journal of The American Academy of Dermatology” This study investigated the use of spironolactone in patients with estrogen-dependent cancers, aiming to determine if it is linked to increased cancer recurrence risk, but results are not reported.
130 citations
,
January 1994 in “Differentiation” In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.
August 2023 in “Cell Proliferation” This study observed that incorporating human follicle dermal papilla cells into fibrin microgels increased cell viability and the formation of hair follicle structures in in vitro skin cultures compared to traditional dermal papilla spheroids, suggesting a promising approach for hair follicle regeneration therapies.
1 citations
,
November 2023 in “Journal of cosmetic dermatology” This study developed a novel antidandruff shampoo with ketoconazole-coated zinc oxide nanoparticles that showed enhanced antifungal activity against Malassezia furfur compared to standard ketoconazole treatments, suggesting it could be a more effective alternative for dandruff management.
50 citations
,
May 2020 in “FEBS Letters” This review discusses techniques for analyzing the cell cycle, highlighting emerging tools for measuring cell cycle speed at single-cell resolution in live animals, and reports no new results.
47 citations
,
July 1967 in “Science” This study observed morphological changes in scalp hair follicles of humans deprived of protein for 15 days, which suggests potential use in diagnosing protein-calorie malnutrition.
12 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that hair follicle cells' growth in vitro is influenced by the concentration of androgens and antiandrogens, with papilla cells and outer root sheath keratinocytes showing distinct sensitivity.
11 citations
,
January 1997 in “Skin Pharmacology and Physiology” This study found that bisindolylmaleimide PKC inhibitors increased DNA synthesis in mouse hair follicles, suggesting that PKC may inhibit hair follicle proliferation.
8 citations
,
May 1996 in “Endocrinology” This study found that the androgen precursors DHEA and androstenedione stimulated androgen-sensitive parameters in the sebaceous glands of the skin in castrated male hamsters.
121 citations
,
March 1989 in “Journal of Investigative Dermatology” Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.
87 citations
,
March 2005 in “Journal of Dermatological Science” This study found that the extract of Asiasari radix may promote hair growth in mice by enhancing protein synthesis, cell proliferation, and growth factor expression.
44 citations
,
March 2004 in “Journal of Investigative Dermatology” This study observed that in vitro treatment of male frontotemporal scalp hair follicles with 17-β-estradiol stimulated hair shaft generation and hair matrix keratinocyte proliferation, suggesting potential anagen-prolonging effects.
37 citations
,
November 1995 in “Journal of Investigative Dermatology” This study found that topical finasteride and flutamide both significantly reduced sebaceous gland growth and decreased prostatic weights in hamsters, indicating systemic effects despite local application.
26 citations
,
December 2006 in “Endocrinology” This study found that a topical cream containing PTH (7–34) significantly stimulated hair growth in hairless mice.
24 citations
,
January 1993 in “Dermatologic Clinics” Minoxidil effectively treats hair loss, works better for women, and requires consistent use.
17 citations
,
January 1985 in “International Journal of Dermatology” In this study, minoxidil was found to suppress the activity of normal human T-lymphocytes in vitro, though the physiological relevance of this effect remains uncertain.
10 citations
,
September 1997 in “Molecular carcinogenesis” This study found that mirex and TPA promote papilloma formation in CD-1 mouse skin through distinct populations of mutant Ha-ras cells, resulting in additive tumor yields.
4 citations
,
July 2008 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that alopecia areata patients who responded poorly to topical immunotherapy had impaired peripheral blood mononuclear cell responses to T-cell stimulants.
333 citations
,
February 2010 in “Cell Stem Cell” This review discusses experimental data, technologies, and genetic factors related to stem cell niches, highlighting their role in tissue regeneration and diseases, but reports no new results.
81 citations
,
February 1997 in “Journal of Investigative Dermatology” This study suggests that minoxidil activates PGHS-1, which may explain its hair growth-stimulating effects and could aid in designing more potent hair growth-promoting drugs.
27 citations
,
April 1992 in “Biochemical Journal” Minoxidil reduces lysine hydroxylase in skin cells.
23 citations
,
March 1988 in “Biochemical Pharmacology” This study found that minoxidil inhibited prostacyclin production in various endothelial and smooth muscle cells in culture without affecting the synthesis of other cyclooxygenase products.
581 citations
,
February 1998 in “The American Journal of Medicine” This review discusses the potential adverse effects of herbal remedies, such as allergic reactions and drug interactions, and reports no new clinical findings; the authors suggest the risks might be underestimated.