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Glossary Telogen Phase

hair follicles are inactive, and hair naturally falls out

The Telogen Phase, also known as the Resting Phase or hair shedding phase, is the final stage of the hair growth cycle. During this phase, hair follicles are inactive, and the hair strand is fully formed but not actively growing. This phase typically lasts around 2-4 months, after which the hair naturally falls out, making way for new hair growth in the subsequent Anagen Phase.

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research Identification of microRNAs in Wool Follicles during Anagen, Catagen, and Telogen Phases in Tibetan Sheep

37 citations , October 2013 in “PLoS ONE”

This study provides new insights into the identification and expression patterns of miRNAs in wool follicles, which could improve understanding of wool follicle development in sheep.

research Identification of Telogen Markers Underscores that Telogen Is Far from a Quiescent Hair Cycle Phase

21 citations , November 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that telogen, a resting phase of the hair follicle cycle, is characterized by dynamic gene expression, including enhanced cholesterol metabolism and immune signaling, suggesting it is an active regulatory phase despite its quiescent appearance.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

6 citations , November 2013 in “International Journal of Radiation Biology”

In this study, γ-ray irradiation of mice reduced hair follicle density and pigmentation, suggesting damage to stem cells and progenitors for keratinocytes and melanocytes.

research Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase

5 citations , March 2022 in “Frontiers in Cell and Developmental Biology”

This study found that exosomes derived from bovine colostrum promoted hair growth in mice by activating the Wnt/β-catenin pathway, with effects similar to minoxidil but without adverse effects.

research Telogen Phase of Hair Growth Cycle Is Regulated by Cyclic Epithelial FGF18 Signaling

1 citations , December 2012 in “Journal of Dermatological Science”

FGF18 controls hair growth rest phase.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

November 2013 in “Institutional Repositories DataBase (IRDB)”

In this study, γ-ray exposure in mice decreased hair follicle density and pigmentation, suggesting damage to stem cells affecting hair follicle regeneration.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

November 2013 in “Institutional Repositories DataBase (IRDB)”

In this study, γ-ray irradiation in mice during the first telogen phase led to decreased hair follicle density and pigmentation anomalies, suggesting damage to stem cells and progenitors for keratinocytes and melanocytes.

research Expression of E6 and E7 papillomavirus oncogenes in the outer root sheath of hair follicles extends the growth phase and bypasses resting at telogen.

10 citations , October 2000 in “PubMed”

This study found that transgenic mice expressing HPV E6/E7 in the outer root sheath experience continuous hair follicle cycling due to delayed catagen entrance and insensitivity to telogen resting signals.

research Comparative Studies of the Diameters of Hairshafts in Anagen and in Telogen Phases in Male Adults Without Alopecia and in Male Adults With Androgenetic Alopecia

6 citations , January 1981

research Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle

161 citations , June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the switch-off of melanogenesis during the hair cycle in C57 BL-6 mice is a gradual and stochastic process starting in mid anagen VI, with specific biochemical markers indicating the transition to catagen.

research Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling

158 citations , February 2012 in “Journal of Investigative Dermatology”

FGF18 helps keep hair in its resting phase, affecting hair growth cycles.

Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

research Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice

113 citations , November 2017 in “Scientific Reports”

This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.

research Telogen Effluvium: A Review

70 citations , January 2015 in “Journal of Clinical and Diagnostic Research”

This review discusses the various triggers and diagnostic challenges in determining the cause of telogen effluvium-related hair loss, without providing new clinical results.

research Telogen effluvium: a comprehensive review

56 citations , August 2019 in “Clinical, Cosmetic and Investigational Dermatology”

This essay discusses telogen effluvium, the issues surrounding its diagnosis and differentiation from other forms of hair loss, and emphasizes the need for empathetic patient care; it reports no new clinical findings.

Atrophic Telogen Effluvium from Cytotoxic Drugs and a Randomized Controlled Trial to Investigate the Possible Protective Effect of Pretreatment with a Topical Vitamin D3 Analogue in Humans

research 'Atrophic telogen effluvium' from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D3 analogue in humans

47 citations , July 2005 in “British Journal of Dermatology”

This study found no protective effect of topical calcipotriol on hair loss in chemotherapy patients, and the authors propose the term "atrophic telogen effluvium" for this type of hair loss.

Telogen Effluvium Due to Recombinant Interferon Alpha-2b

research Telogen Effluvium due to Recombinant Interferon α-2b

45 citations , October 2009 in “Dermatology”

This study observed that long-term recombinant interferon alpha-2b therapy was associated with considerable hair loss in some patients, indicated by a telogen effluvium pattern on trichograms.

research The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin

42 citations , March 2014 in “European Journal of Pharmacology”

This study found that minor ginseng saponin F2 may promote hair growth more effectively than finasteride by enhancing anagen induction and modulating the Wnt signaling pathway in cell and mouse models.

research Estrogen Leads to Reversible Hair Cycle Retardation through Inducing Premature Catagen and Maintaining Telogen

42 citations , July 2012 in “PLOS ONE”

This study found that estrogen can cause reversible suppression of the hair cycle by inducing premature catagen and maintaining the telogen phase without damaging the hair follicle stem cell niche or the signature gene expressions of dermal papilla cells.

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

32 citations , April 2016 in “Journal of Investigative Dermatology”

This study found that STAT5 activation in the dermal papilla acts as a key switch to trigger anagen entry in postdevelopmental hair follicle cycling.

research Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte‐mediated growth inhibition of anagen‐phase vibrissa hair

30 citations , October 2014 in “Experimental Dermatology”

This study found that leptin from dermal white adipose tissue may regulate hair growth and cycle progression through its receptor on hair follicle epithelium in mice and humans.

research Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling

25 citations , April 2015 in “Journal of Investigative Dermatology”

This study found that Gsdma3 mutation in mice allows hair follicles to bypass a typical telogen phase and directly enter the anagen phase, suggesting Gsdma3's role in hair cycle transitions by regulating Wnt signaling.

Telogen Effluvium: Causes, Diagnosis, and Treatments

research Telogen Effluvium

18 citations , March 2016 in “Cosmetics”

This review discusses telogen effluvium, including its triggers, clinical presentations, and management options, and does not report new research findings, emphasizing the need for identification and exclusion of underlying causes.

research Hirsutism, postpartum telogen effluvium, and male pattern alopecia

17 citations , March 2006 in “Journal of Cosmetic Dermatology”

This review discusses various factors influencing hair growth, including alopecia and hirsutism, and highlights recent advancements in treatment approaches without reporting new clinical results.

research Telogen Effluvium as a Sign of Hodgkin Disease

13 citations , November 1973 in “Archives of Dermatology”

This report describes a case where severe hair loss occurred as an early manifestation of Hodgkin disease, with the literature suggesting it might result from follicle destruction or toxic effects.

research A histochemical examination of the epidermis of the southern elephant seal (Mirounga leonina L.) during the telogen stage of hair growth

8 citations , February 1968 in “Australian Journal of Zoology”

This study describes the structure and composition of the epidermal horny layer in elephant seals, noting that its keratinized cells are attached without a specialized fission zone, differing from the sloughing mechanism in reptiles.

A Spermidine-Based Nutritional Supplement Prolongs the Anagen Phase of Hair Follicles in Humans: A Randomized, Placebo-Controlled, Double-Blind Study

research A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study

8 citations , October 2017 in “Dermatology practical & conceptual”

This study found that a spermidine-based nutritional supplement increased the number of anagen phase hair follicles in healthy humans, suggesting potential benefits for hair loss conditions.

research Postpartum telogen effluvium

7 citations , January 2015 in “Journal of the European Academy of Dermatology and Venereology”

This letter to the editor on postpartum telogen effluvium does not include new research findings or data.

research Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis

7 citations , August 2020 in “Genes”

This study mapped gene expression in different skin structures of dogs, finding similarities to humans that support using dogs as models for human skin diseases.

$Dietary Vitamin A Impacts Refractory Telogen$

research Dietary Vitamin A Impacts Refractory Telogen

6 citations , February 2021 in “Frontiers in Cell and Developmental Biology”

This study suggests that vitamin A may inhibit hair follicle stem cells during refractory telogen in a dose-dependent manner, based on retinyl ester levels and vitamin A metabolism protein localization in mice.

research Telogen elongation in the hair cycle of ob/ob mice

5 citations , August 2015 in “Bioscience, Biotechnology, and Biochemistry”

In this study, ob/ob mice were found to have a prolonged telogen hair cycle phase from 10 to 24 weeks, suggesting their potential as a model for studying telogen effluvium.