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    Glossary Regulatory T Cells

    specialized immune cells that prevent autoimmune responses

    Regulatory T Cells, often abbreviated as Tregs, are a specialized subset of T cells in the immune system that help maintain immune tolerance and prevent autoimmune diseases. They function by suppressing the activity of other immune cells, thereby preventing excessive or misdirected immune responses that could damage the body's own tissues.

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    1. Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease PloS one · 2019 · 30 citations
    2. Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing its Impact on T Regulatory Cell and NK Cell Populations 2020 · 22 citations
    3. A humanized IL-2 fusion protein enhances T regulatory cells in vivo and restrains disease in a murine model of Alopecia Areata 4760 The Journal of Immunology · 2025
    4. The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris Frontiers in Immunology · 2022 · 49 citations
    5. HuR ablation destabilizes Foxp3 mRNA and impairs regulatory T cell function, contributing to an autoimmune phenotype Frontiers in Immunology · 2025 · 1 citations
    6. Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers International Journal of Molecular Sciences · 2023 · 1 citations
    7. 039 Expansion of regulatory T Cells restrains pathogenic CD8 T Cells in a murine model of alopecia areata Journal of Investigative Dermatology · 2024
    8. The potential of regulatory T cell-based therapies for alopecia areata Frontiers in Immunology · 2023
    9. Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues 2013 · 140 citations
    10. Regulatory T Cells in Autoimmune Diseases and their Potential Journal of Investigative Dermatology Symposium Proceedings · 2005 · 3 citations
    11. Role of regulatory T cells in psoriasis pathogenesis and treatment British Journal of Dermatology · 2020 · 273 citations
    12. T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities 2018 · 66 citations
    13. Imbalance of T‐helper 17 and regulatory T cells in patients with alopecia areata The Journal of Dermatology · 2015 · 62 citations
    14. CD80CD86 deficiency disrupts regulatory CD4+FoxP3+T cell homoeostasis and induces autoimmune-like alopecia Experimental dermatology · 2017 · 6 citations
    15. Distinctive T Cell Patterns Defining Lymphocytic Alopecia and Alternate Autoimmune and Stem Cell Pathways, Linked to Pleiotropic Functions of Regulatory T Cells Within iSALT American Journal of Dermatopathology · 2026
    16. 001 Human scalp hair follicles are protected from alopecia areata in vivo by regulatory γδT cells Journal of Investigative Dermatology · 2024
    17. Human regulatory γδT lymphocytes as novel autoimmunity-protective cells: Lessons from alopecia areata 2024
    18. 52993 Regulatory γδ T cells protect human scalp hair follicles from alopecia areata in vivo Journal of the American Academy of Dermatology · 2024
    19. 185 Regulatory γδ T cells protect human scalp hair follicles from alopecia areata in vivo Journal of Investigative Dermatology · 2023
    20. 42905 Role of regulatory T and T-helper 17 cells in patients with acute diffuse and total alopecia Journal of the American Academy of Dermatology · 2023
    21. 068 Pathogenic Th17 cells, CD8+CD69+CD49a- tissue-resident memory T cells and common γ chain receptor + natural killer cells express more IL-17, compared to IFN-γ, under the foxp3+ memory regulatory T cells-depleted microenvironment in patients with chronic alopecia areata Journal of Investigative Dermatology · 2023
    22. Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration Frontiers in Immunology · 2018 · 188 citations
    23. Regulatory T cells in skin Immunology · 2017 · 110 citations
    24. Regulatory T cells in inflammatory skin disease: from mice to humans International immunology · 2019 · 43 citations
    25. Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity 2019 · 39 citations
    26. Regulatory T cells in dominant immunologic tolerance Journal of Allergy and Clinical Immunology · 2023 · 26 citations
    27. Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease Frontiers in Immunology · 2022 · 9 citations
    28. Regulatory T cells in skin regeneration and wound healing 2023 · 3 citations
    29. Regulatory T cell dysfunction and immunotherapeutic breakthroughs in type 1 diabetes Frontiers in Endocrinology · 2026 · 2 citations
    30. Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration Cell Reports · 2025