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Protein tyrosine kinases are key in male pattern baldness, affecting skin structure, hair growth, and immune responses.

Alopecia areata needs more recognition and better treatment access in Latin America to improve patient care and outcomes.

Finasteride may cause lasting sexual and mental health issues, and genetic screening could help prevent them.

TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

Mast cells and CD8 T cells interact closely in skin diseases, affecting each other's behavior and contributing to conditions like psoriasis and eczema.

Plasmalogens activate a channel in cells that may stimulate hair growth.

Cytotoxic T cells cause hair loss in chronic alopecia areata.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Thymosin β4 helps improve skin healing and reduce scarring.

Human prenatal skin develops an immune network early on that helps with skin formation and healing without scarring.

Interferons are effective for some skin conditions and cancers, but can have side effects and need more research for optimal use.

The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The research reveals how early embryonic mouse skin develops from simple to complex structures, identifying various cell types and their roles in this process.

Aged individuals heal wounds less effectively due to specific immune cell issues.

Lower CD200R1 on certain immune cells is linked to more severe rheumatoid arthritis and immune imbalance.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Cepharanthine, a Japanese hair loss drug, shows promise as a COVID-19 treatment but needs more testing.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Alopecia Areata is a complex, unpredictable autoimmune hair loss condition with limited treatment options and a significant psychological impact.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

Patients with RASopathies have a higher risk of autoimmune disorders and should be routinely screened.

Melatonin directly affects mouse hair follicles and may influence hair growth.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Tofacitinib citrate is effective for moderate-to-severe chronic plaque psoriasis but has safety concerns at higher doses.