29 citations
,
January 2016 in “CNS drugs” This review of teriflunomide for relapsing-remitting multiple sclerosis examines its clinical and safety outcomes, finding it significantly reduces relapse rates and disability progression while being generally well-tolerated.
27 citations
,
April 2017 in “British Journal of Dermatology” This study identified overexpression of certain immune-related genes and underexpression of genes in specific signaling pathways in premature androgenetic alopecia, suggesting potential new therapeutic targets.
24 citations
,
July 1994 in “Molecular Endocrinology” Researchers found an RNA transcript that might help control a growth factor linked to tumor development.
21 citations
,
January 2019 in “Experimental dermatology” This review explores how low-energy He-Ne laser therapy may stimulate repigmentation in vitiligo by affecting mitochondrial pathways and melanocyte function, but does not report new clinical results.
18 citations
,
June 2009 in “Journal of Molecular Endocrinology” This study found that exposure to finasteride impaired spermatogenesis in male Xenopus laevis by affecting sex-specific feedback mechanisms in the hypothalamus–pituitary–gonad axis.
15 citations
,
January 2015 in “Skin Pharmacology and Physiology” This study indicates that targeting the PTH/PTHrP receptor may potentially stimulate hair growth, particularly for chemotherapy-induced alopecia, as observed in hairless and cyclophosphamide-treated mice.
11 citations
,
February 2022 in “Scientific Reports” This study found that CD26+ fibroblasts are crucial for effective extracellular matrix production and achieving rapid epidermal and dermal homeostasis in human tissue-engineered skin substitutes transplanted onto rodents.
8 citations
,
December 2018 in “Journal of Dermatological Treatment” This study found that a PRP-like cosmetic product called TR-M-PRP plus significantly improved hair growth in individuals with alopecia areata over three months, as measured by the SALT score, suggesting it could be a safer alternative to traditional PRP treatments.
4 citations
,
October 2021 in “Scientific Reports” This study found that NKIRAS2 expression affects skin tumor suppression and HRAS-driven transformation in mice, indicating its role in carcinogenesis depends on expression level and cellular context.
4 citations
,
June 1998 in “The Journal of Clinical Endocrinology & Metabolism” This study found that keratinocyte growth factor is a potent mitogen in human hyperplastic prostate cells, suggesting it plays an important role in prostate growth by acting in a paracrine manner.
3 citations
,
May 2018 in “Reproductive Sciences” In this randomized study, BAY 1158061, a prolactin receptor antibody, was found to be safe, well-tolerated, and exhibited low immunogenicity in healthy postmenopausal women, but had no effect on serum prolactin levels compared to placebo.
1 citations
,
July 2024 in “International Journal of Dermatology Venereology and Leprosy Sciences” This review discusses various environmental and chemical factors that contribute to hair shaft disorders, such as fractures, and highlights the potential roles of cysteine and glutamine in hair health, but reports no new results.
December 2025 in “Al-Iraqia Medical College Journal” This study explored the relationships between virus susceptibility to infection and several factors, finding that higher heat tolerance and larger virus size correlated positively with infection susceptibility, while high humidity and higher mutation rates correlated inversely among eight RNA viruses, including SARS-CoV-2 and influenza.
November 2025 in “Quality in Sport” This review found that hydrolyzed collagen supplementation, particularly marine collagen, improves skin hydration, elasticity, and density while strengthening hair and nails, especially when paired with vitamin C and trace elements; however, more studies are necessary to evaluate long-term efficacy across different sources and demographics.
October 2017 in “The Indian Journal of Animal Sciences” This study found that prolactin gene polymorphism in Changthangi goats showed no significant association with Cashmere quality traits, indicating the need for further research with larger sample sizes.
December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)” This study suggests that the adrenal gland may contribute to prostate cancer treatment resistance and indicates potential steroid production or dependency in ovarian cancer.
142 citations
,
December 1991 in “Antimicrobial Agents and Chemotherapy” This study reported that continuous intravenous dextran sulfate was toxic and ineffective as a treatment for symptomatic HIV infection, as it did not improve surrogate markers and caused significant side effects.
119 citations
,
March 2020 in “Frontiers in Bioengineering and Biotechnology” This review provides an overview of recent tissue engineering and regenerative medicine developments in Asia, highlighting significant advances, representative research achievements, and discussing future directions, without presenting new research results.
77 citations
,
August 2025 in “Signal Transduction and Targeted Therapy” This review highlights the potential of extracellular vesicle-based therapies for treating various diseases, but it also notes challenges like the lack of regulatory guidelines that hinder their clinical development.
42 citations
,
January 2011 in “Journal of Biomedical Optics” This study demonstrates that spatially resolved IR and Raman imaging can effectively reveal the molecular structure and composition of untreated human hair, providing insights into its chemistry and structural integrity.
18 citations
,
March 2006 in “Expert Review of Neurotherapeutics” This review outlines strategies for preventing, identifying, and managing complications related to current MS therapies and reports no new clinical results, emphasizing the growing complexity in MS treatment regimens.
4 citations
,
January 2015 in “Sen'i Gakkaishi” This study proposed a network model for the cross-linked structure of keratin-associated proteins in hair and wool fibers, suggesting notable differences between the two, potentially affecting hair fiber elasticity.
451 citations
,
March 2005 in “Endocrine Reviews” This paper discusses the role of steroid sulfatase in hormone-dependent tumors and highlights the development of potent inhibitors, noting the commencement of a phase I trial for one inhibitor in postmenopausal breast cancer patients.
421 citations
,
January 2015 in “Chemical Society Reviews” This review discusses recent advances in surface modification and endothelialization of biomaterials for vascular grafts, highlighting promising methods like gene engineering and targeting ligand immobilization to improve clinical outcomes.
277 citations
,
July 2011 in “Journal of the Dermatology Nurses’ Association” The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.
234 citations
,
April 2000 in “Gene” This review discusses the expression patterns and biochemical roles of Msx and Dlx genes during development but does not present new research findings.
156 citations
,
January 1989 in “Genes & Development” This study found that keratin K14 expression occurs early in epidermal cell differentiation, while a hair-specific keratin is expressed later in hair matrix cells, suggesting developmental divergence between the two cell types.
139 citations
,
December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a new type II cytokeratin, named K6hf, exclusively expressed in the companion layer of the human hair follicle, distinguishing it from other keratins and suggesting a unique biochemical role.
97 citations
,
March 2009 in “Dermato-endocrinology” This review explores the role of hormones in pilosebaceous units and associated skin disorders, focusing on androgen action, without presenting new clinical findings.
80 citations
,
April 2011 in “Plant physiology” This study suggests that the GPX-PDE1 and GPX-PDE2 genes in white lupin enhance root hair development and contribute to Pi limitation acclimation by facilitating glycerophosphodiester degradation.