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Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Patients need long-term care after bariatric surgery to manage potential nutritional and metabolic issues.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Oral minoxidil promotes hair growth but may cause side effects; needs monitoring.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

Spironolactone improved blood vessel function and cholesterol levels in non-obese women with PCOS.

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.

Foxi3 expression in developing teeth and hair is controlled by the ectodysplasin pathway.

Bariatric surgery may help severely obese teenagers but has risks and requires careful patient selection and long-term care.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

Scientists have made progress in creating replacement teeth, hair, and glands that work, which could lead to new treatments for missing teeth, baldness, and dryness conditions.

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

New drugs and combination therapies are improving treatment for lower urinary tract symptoms.

The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.

Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.

Hair in mammals likely evolved from glandular structures, not scales.