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The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

PTHrP and its receptor can control blood vessel growth and hair development in mouse skin.

Regulatory T cells are essential for normal and improved wound healing in mice.

PRP shows promise for improving facial wrinkles, skin elasticity, and hair growth, but more research is needed to standardize its use and understand its effects.

Both human and animal-derived small extracellular vesicles speed up skin healing equally well.

DHT is a strong androgen that may pose less risk to the prostate compared to testosterone.

Early treatment and lifestyle changes are important for managing PCOS in young people to prevent long-term health issues.

The skin's dermal layer contains true stem cells with diverse functions and interactions that need more research to fully understand.

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

Platelet-rich plasma may not be very effective for bone healing and hair growth due to a substance it contains that blocks these processes.

WNT10B is linked to cancer development and affects survival and disease progression in various cancers.

Low-level laser therapy may help stem cells grow and function better, aiding in healing and tissue repair.

Melatonin directly affects mouse hair follicles and may influence hair growth.

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Special fiber materials boost the healing properties of certain stem cells.

The peptide GHK-Cu helps heal and remodel tissue, improves skin and hair health, and has potential for treating age-related inflammatory diseases.

Latanoprost can make eyelashes longer, thicker, and darker.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

The research identified various cell types in mouse and human teeth, which could help in developing dental regenerative treatments.

Survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis need ongoing care for various long-term health problems.