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Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The Rotterdam Study aims to understand various diseases in older adults.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Fibrinogen/LDL apheresis may improve speech perception in sudden hearing loss, especially for those with high fibrinogen and LDL levels.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Women with PCOS face higher risks of diabetes and heart disease, and these risks increase with obesity.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

PEVs improve minoxidil skin penetration, increasing hair growth.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Toxic epidermal necrolysis is a severe skin condition often caused by drugs, with complex treatment and a high risk of death, but survivors usually heal without scars.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.

Iron deficiency common in women, not always linked to hair loss; more research needed.

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Doctors need to be better prepared to assess and treat obesity in patients.

Neurosteroids show promise for treating epilepsy and more research is needed.

Microneedle technology has improved drug delivery and patient comfort but needs more research for broader use.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Dermatologists play a key role in treating skin symptoms of PCOS like dark patches, excess hair, acne, and hair loss.