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Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Acne is caused by multiple factors including oil production, bacteria, inflammation, and possibly diet and environment.

Vitamin D3 may protect rat hair follicles from radiation damage.

1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.

We need better ways to test and understand SARMs to make safer and more effective treatments.

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

The baby’s hair loss was due to a rare genetic condition, not treatable by usual methods.

Androgens may worsen COVID-19 and hair loss could indicate the disease's severity.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Children with atopic dermatitis often have sleep problems due to itching and may benefit from melatonin, which helps with sleep and skin symptoms.

Different women's hair and skin glands respond to hormones in varied ways, which can cause unwanted hair growth even with normal hormone levels, and more research is needed to treat this effectively.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.