38 citations
,
November 2000 in “Hastings Center Report” This paper argues that both the modern biomedical model and existing supplementary frameworks fail to adequately capture the complexities of empathy and healing within the context of postmodern thinking.
38 citations
,
January 2013 in “Analyst” This study identified the main secondary metabolites in Ziziphus jujuba seeds and confirmed that UPLC-MS/MS and GC-MS effectively demonstrate their pharmaceutical quality.
38 citations
,
October 2001 in “British Journal of Dermatology” This study identified a new keratin, K6irs, as a potential histological marker for the inner root sheath of hair follicles in mice and humans, and as a candidate gene for hereditary hair defects.
34 citations
,
January 2016 in “Analytical Chemistry” This study reports that a new DART-HRMS method can effectively analyze intact hair for drug use timelines, with cocaine detection aligning with forensic standards and identifying multiple drugs from high-resolution data.
33 citations
,
February 2016 in “Journal of Experimental Botany” This study found that the receptor kinase RHS10 negatively regulates root hair growth in Arabidopsis thaliana by modulating growth duration and is associated with cell wall signal mediation, involving RNA catabolism and ROS accumulation.
31 citations
,
June 2020 in “Dermatologic Therapy” This systematic review reports that for patients with underlying dermatologic disorders who contracted COVID-19, most experienced mild to moderate exacerbation of their skin conditions and were managed similarly to the general population, suggesting treatment discontinuation during acute infection may prevent severe recurrence.
31 citations
,
January 2001 in “PubMed” In this randomized study of male contraceptive regimens, adding finasteride did not significantly enhance spermatogenesis suppression compared to the control group.
30 citations
,
June 2017 in “Talanta” This review discusses the critical parameters for MALDI IMS sample preparation in skin analysis and highlights its applications in wound healing, neoplasia, and infection research, but reports no new clinical results.
30 citations
,
April 2011 in “Rapid communications in mass spectrometry/RCM. Rapid communications in mass spectrometry” This study found that using hair steroid profiling, dutasteride treatment led to reduced dihydrotestosterone levels and DHT/testosterone ratio in patients with male-pattern baldness.
29 citations
,
July 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that in mouse hair follicles, enzymes Aldh1a2 and Aldh1a3 have distinct expression patterns that suggest they are involved in different signaling pathways during the hair cycle.
28 citations
,
April 2009 in “Annals of laboratory medicine” This study found that the DFS pattern occurs in about 28% of ANA-positive cases and is relatively frequent in autoimmune diseases, contrary to previous observations suggesting no link with these diseases.
27 citations
,
April 2013 in “Reviews in endocrine and metabolic disorders” The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.
27 citations
,
June 2015 in “Journal of Investigative Dermatology” This study found that mutations in the TRPV3 gene can cause a broader range of symptoms in Olmsted syndrome than previously recognized, including severe palmoplantar keratoderma without other classic features.
25 citations
,
January 2019 in “British Journal of Dermatology” Low oxygen levels can make hair-growing cells better at growing hair through a process involving reactive oxygen species.
25 citations
,
January 2013 in “Colloids and surfaces. B, Biointerfaces” This study found that melanin granules in black human hair are key dyeing regions for oxidative hair coloring, as confirmed by nanoscale mass spectrometry analysis detecting deuterium ions.
25 citations
,
November 2010 in “Journal of Molecular Structure” This preliminary study suggests that Raman micro-spectroscopy can help differentiate basal cell carcinoma from hair follicles in skin tissue sections, although some misclassification of hair follicles as carcinoma was observed.
24 citations
,
July 2017 in “Structure” In this study, researchers found that ligand homodimerization controls the receptor binding specificity of the FGF9 subfamily, preventing off-target activation of FGFR "b" isoforms.
24 citations
,
July 2015 in “Molecular Medicine Reports” This study found that lysophosphatidic acid increases mesenchymal stem cell proliferation and migration through signaling pathways and reactive oxygen species, implicating potential applications in stem cell expansion.
23 citations
,
January 2024 in “Nature Immunology” This study, using multimodal profiling in mice, found that various tissues contain unique γδ T cell subsets adapted to their environment, revealing their functional diversity, lineage relationships, and similarities to CD8+ tissue-resident memory T cells.
22 citations
,
January 2021 in “Clinical Therapeutics” This review discusses sex and gender differences in COVID-19 presentation, treatment, and outcomes, and reports no new clinical findings.
22 citations
,
September 2014 in “JAMA dermatology” This study identified major criteria including ectodermal malformations for diagnosing ichthyosis with confetti, and revealed significant genetic variation in the disease locus within the general population.
21 citations
,
January 2018 in “Anticancer Research” This study suggests that NBCCS and BFHS may be the same genetic condition, which could help improve identification and management of misdiagnosed cases with specific surveillance strategies.
21 citations
,
October 2011 in “PloS one” In this study, researchers identified three molecules in hair that varied with age, suggesting potential markers for aging and targets for cosmetic products.
21 citations
,
February 2003 in “Hormones and Behavior” This study found that testosterone combined with progesterone stimulated digging behavior in ovariectomized rabbits but also reduced food intake, an effect partially counteracted by progesterone.
20 citations
,
December 1995 in “Journal of Chromatography B: Biomedical Sciences and Applications” Accurate method measures finasteride levels in human plasma using gas chromatography-mass spectrometry.
20 citations
,
August 2014 in “Talanta” This study developed a novel method to simultaneously measure finasteride, dutasteride, and related biomarkers in serum, finding that both drugs lowered DHT levels while increasing substrate concentrations.
19 citations
,
April 2024 in “Nature Cell Biology” 19 citations
,
March 2021 in “Applied Materials Today” This study found that silk fibroin gel induced more pro-regenerative macrophages and hair follicle stem cells, leading to almost scarless skin regeneration compared to alginate gel.
19 citations
,
May 2019 in “JAMA dermatology” This study found that patients with alopecia areata had an increased risk of mortality from self-harm, psychiatric diseases, and lung cancer compared to the general population.
19 citations
,
December 2015 in “European Journal of Human Genetics” This study found that a novel rare variant in ITGB6 may cause intellectual disability, alopecia, and dentogingival anomalies in a specific Pakistani family, highlighting a potential role for ITGB6 beyond enamel formation.