9 citations
,
March 2023 in “Chemosphere” This study found that exposure to certain pesticides may be associated with delayed sexual maturation in adolescent males.
35 citations
,
January 2012 in “The Journal of Sexual Medicine” This review examines various androgen deprivation therapy methods for advanced prostate cancer, highlighting benefits and potential cardiovascular and sexual adverse effects, but reports no new clinical results.
2 citations
,
January 2023 in “Sexual Medicine” This study found that the MTCK, a masturbation aid, significantly improved intravaginal ejaculation latency time and some related sexual function scores in men with premature ejaculation after 8 weeks of use.
2 citations
,
January 2000 in “Pediatrics in review” This article discusses diagnostic evaluations and management strategies for isosexual precocious puberty, emphasizing the importance of accurate identification and appropriate treatment, but it provides no new clinical findings.
1 citations
,
April 1936 in “Journal of Experimental Biology” This study found that injecting thymus gland extracts into albino rats significantly accelerated growth and morphological differentiation across generations, including earlier sexual maturation and development of features like hair and teeth.
24 citations
,
October 2016 in “Oncotarget” This study found that finasteride was associated with more reproductive adverse effects, including sexual dysfunction in men and fetal harm in women, compared to minoxidil in reported alopecia cases.
192 citations
,
January 1976 in “The Journal of Clinical Endocrinology & Metabolism” This study observed that androgen levels rise with pubic hair development in Tanner stages, differing by sex and age, with DHEA showing a significant prepubertal increase especially in precocious adrenarche.
27 citations
,
February 2005 in “Journal of Cellular Biochemistry” This study found that rat male costochondral chondrocytes, unlike female chondrocytes, respond to testosterone through metabolism to dihydrotestosterone, which shows a maturation-state dependent effect in male growth plate cells.
90 citations
,
October 1998 in “Animal Reproduction Science” This study found that in captive mouflon rams, reproductive and physical maturation, marked by changes in hormone levels and physical attributes, progresses gradually across their life span, with sexual maturity tied closely to physical maturity.
10 citations
,
January 1997 in “The journal of sex research/The Journal of sex research” In this study of HIV+ men with low CD4 and testosterone levels, testosterone replacement therapy significantly improved sexual interest, erectile functioning, and sexual satisfaction over an eight-week period.
37 citations
,
June 2011 in “Pediatrics in Review” This article reviews the physiological changes underlying normal pubertal milestones and emphasizes the importance of understanding these changes to assess pubertal abnormalities, without reporting new clinical findings.
3 citations
,
June 2017 in “Deep Blue (University of Michigan)” This study found that prenatal exposure to fluoride and lead, as well as maternal micronutrient intake, may influence sexual maturation in adolescents in a sex-specific manner.
January 2014 in “Duo Research Archive (University of Oslo)” This study found that steroid hormone treatments significantly reduced mRNA expression of certain Ca2+-activated K+ channel genes in Atlantic cod pituitary cells, suggesting a potential role in sexual maturation regulation.
12 citations
,
January 2013 in “Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz” Older adults still engage in sexual activities but face challenges like health issues and lack of professional support, highlighting the need for better healthcare provider education and research on sexual fulfillment in old age.
26 citations
,
September 2005 in “Pharmacology Biochemistry and Behavior” This study found that inhibiting the 5alpha-reductase 2 pathway in male rats affects brain sexual differentiation and leads to reproductive changes, including increased pre-implantation loss despite unchanged copulatory potential.
November 2023 in “Bioorganic Chemistry” This review provides an overview of clinically approved small molecule drugs targeting androgen receptors and discusses therapeutic applications, without presenting new experimental results.
24 citations
,
July 1983 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” This article reviews the discovery and various physiological effects of cyproterone acetate, reporting its established indications for several androgen-driven conditions but providing no new clinical data.
2 citations
,
November 2012 in “InTech eBooks” The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.
January 1983 in “Elsevier eBooks” This article reviews the discovery and various physiological effects of cyproterone acetate, reporting its established indications for several androgen-driven conditions but providing no new clinical data.
173 citations
,
May 2001 in “Human reproduction update” This review discusses the role of oestrogens in stimulating growth hormone secretion and influencing linear bone growth in children, and reports no new clinical results; the authors suggest that oestrogens play a key role in pubertal growth spurts for both genders.
April 1978 in “Pediatric research” This study found that zinc levels in hospitalized patients with significant weight loss did not correlate with taste perception or vitamin A status, even in those with reduced taste acuity.
25 citations
,
January 2000 in “Hormone Research in Paediatrics” This article reviews androgen insensitivity syndrome and highlights the factors contributing to phenotypic diversity in 46,XY patients with AR gene mutations, reporting no new clinical results.
May 2021 in “Journal of the Endocrine Society” This case report details a diagnosis of adult-onset isolated hypogonadotropic hypogonadism in a 23-year-old African American female, highlighting its genetic basis and treatment approach.
11 citations
,
July 2001 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS” This review discusses the role of oestrogens in stimulating linear bone growth and pubertal changes in both boys and girls, highlighting their influence on the growth hormone-insulin-like growth factor axis; it reports no new clinical results.
10 citations
,
February 2020 in “Endocrine” This study found that finasteride treatment in males with androgenetic alopecia was linked to significant changes in sperm parameters and increased testosterone levels, but no sexual dysfunction was observed, and sperm parameters returned to baseline after treatment stopped.
24 citations
,
December 2013 in “Sexual medicine reviews” This review discusses persistent sexual and nonsexual adverse effects of the 5α-reductase inhibitor finasteride in younger men, including erectile dysfunction, low libido, and depression. It reports no new clinical results but emphasizes further research is needed.
75 citations
,
January 2014 in “Korean Journal of Urology” This review discusses the adverse effects of 5α-reductase inhibitors, finasteride and dutasteride, on sexual, psychological, and vascular health, emphasizing the need for physicians to inform patients of these risks.
14 citations
,
January 2001 in “Primary Care Update for Ob/gyns” This review discusses the challenges in addressing female sexual dysfunction, focusing on the complexities of female sexual response, levels of dysfunction, clinical identification, and existing treatments, but presents no new clinical findings.
13 citations
,
November 2012 in “PubMed” This study found that in men with sexual dysfunction, use of 5ARI may reduce sexual drive and spontaneous erections without worsening pre-existing erectile or ejaculatory issues.
75 citations
,
February 2016 in “The Journal of Sexual Medicine” This review highlights the efficacy of transdermal testosterone therapy in improving sexual function in women with hypoactive sexual desire disorder, though approved formulations and long-term safety data are limited.