Effects of Steroid Hormones on the Expression of Ca2+ Activated K+ Channels in In Vitro Pituitary Cells of Atlantic Cod (Gadus Morhua)

    January 2014 in “ Duo Research Archive (University of Oslo) ”
    Michelle Sætersmoen
    TLDR Steroid hormones may affect sexual maturation in cod by altering certain KCa channel expressions.
    The study investigated the effects of sex steroids on the expression of Ca2+-activated K+ channel genes in Atlantic cod pituitary cells. It found no significant effects of steroid hormones on the mRNA expression of kcnn1, kcnn1a, kcnn2, and kcnma2. However, kcnn3 expression was significantly reduced after cortisol treatment, and kcnn4 expression was significantly reduced after testosterone treatment, with an inhibitory trend observed after dihydrotestosterone treatment. These findings suggested that steroid hormones might regulate sexual maturation partly through KCa channels, although further research was needed to confirm this hypothesis.
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