Normal Pubertal Development: Part I: The Endocrine Basis of Puberty

June 2011 in “ Pediatrics in Review ”

Brian Bordini, Robert L. Rosenfield

hypothalamic-pituitary-gonadal axis adrenal androgen growth hormone gonadal hormone secondary sexual characteristics reproductive functions

TLDR Puberty is driven by hormonal changes, mainly influenced by genetics, nutrition, and body fat.

The article reviewed the endocrine basis of normal pubertal development, focusing on the physiological changes in the hypothalamic-pituitary-gonadal (HPG) axis, adrenal androgen, and growth hormone (GH) production. These changes were crucial for understanding normal pubertal milestones and interpreting laboratory data in children with suspected pubertal abnormalities. Puberty was described as the stage where a child transitions into a young adult, marked by gametogenesis maturation, gonadal hormone secretion, and the development of secondary sexual characteristics and reproductive functions. The article aimed to equip readers with the knowledge to address common concerns about pubertal development and menstrual patterns in children.

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