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Glossary Sebum Excretion Rate

amount of skin oil produced over time

The Sebum Excretion Rate (SER) refers to the amount of sebum, an oily substance produced by sebaceous glands, that is secreted onto the skin's surface over a specific period. This rate can influence skin conditions such as acne and is often measured to assess skin health and diagnose dermatological issues.

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research Effect of the gonadotrophin releasing hormone analogue, goserelin, and oestradiol replacement on sebum excretion rates and hair size in mildly hirsute women

4 citations , January 1991 in “Journal of dermatological treatment”

This study found that GnRH-A treatment significantly reduced hirsuties scores in women with mild idiopathic hirsuties but did not affect hair growth rate or diameter.

research Changes in serum free testosterone, sleep patterns, and 5‐alpha‐reductase type I activity influence changes in sebum excretion in female subjects

10 citations , August 2014 in “Skin research and technology”

This study found that variations in sleep patterns, free testosterone, and 5-alpha-reductase type 1 activity are associated with changes in sebum excretion in women, which may contribute to variability in acne studies.

research Sebum flow dynamics and antidandruff shampoos

2 citations , January 1997 in “Journal of the society of cosmetic chemists”

This study found that among 120 men, two antidandruff shampoos increased sebum excretion rate, while one shampoo decreased sebum output, highlighting distinct effects on the follicular reservoir.

research Sebum Production

1 citations , September 2016 in “Springer eBooks”

This article reports no new data; it describes the role of sebum in influencing the skin microbiome and epithelial tissues and discusses its altered composition during transit through the sebaceous duct.

research EEMCO Guidance for the in vivo Assessment of Skin Greasiness

137 citations , January 2000 in “Skin Pharmacology and Physiology”

This review outlines the factors affecting skin greasiness and sebum production, highlighting measurement challenges but reports no new clinical findings; further research may guide sebosuppressive treatments for acne.

research Oral spironolactone therapy for female patients with acne, hirsutism or androgenic alopecia

101 citations , January 1985 in “British Journal of Dermatology”

This article discusses oral spironolactone therapy for female patients with acne, hirsutism, or androgenic alopecia and reports no new clinical results.

research Clinical, ultrasound and hormonal markers of androgenicity in acne vulgaris

57 citations , August 1995 in “British Journal of Dermatology”

In this study, acne severity in females was strongly associated with inflammatory lesion count and moderately associated with androgens, especially DELTA 4 and DHEAS promoting acne and SHBG reducing it.

research Is seborrhea a sign of autonomic impairment in Parkinson's disease?

46 citations , November 1997 in “Journal of Neural Transmission”

Seborrhea in Parkinson's disease may be linked to hormones, not autonomic impairment.

research An inherited nail dystrophy principally affecting the great toenails

11 citations , January 1985 in “British Journal of Dermatology”

The document concludes that an inherited nail condition often improves on its own, and spironolactone effectively treats acne in women.

research Urinary 5-ene-steroid excretion in non-classical congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency (NC-3BHSD)

3 citations , May 1990 in “Journal of Steroid Biochemistry”

This study found that diagnosing non-classical 3 beta-hydroxysteroid dehydrogenase deficiency solely based on elevated serum or urinary 5-ene-steroids may not be reliable.

research Female pattern hair loss, sebum excretion and the end-organ response to androgens

31 citations , October 2005 in “British Journal of Dermatology”

This study found that sebum excretion is not increased in women with female pattern hair loss, suggesting nonandrogenic factors may contribute to hair loss in some women without hirsutism.

research Effect of biotin on hair roots and sebum excretion in women with diffuse alopecia.

3 citations , January 1966 in “PubMed”

research Effects of an oral contraceptive containing chlormadinone acetate and ethinylestradiol on hair and skin quality in women wishing to use hormonal contraception

6 citations , March 2012 in “Journal of the European Academy of Dermatology and Venereology”

This study found that 12 cycles of chlormadinone acetate in hormonal contraceptives significantly improved oily skin and hair quality, enhancing psychosocial well-being in healthy women.

research Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall

14 citations , September 2020 in “Clinical, cosmetic and investigational dermatology”

This study found that a hair serum containing amla extract, freeze-dried coconut water, and selenium significantly improved hair growth rate, density, and reduced hair fall among healthy volunteers over 90 days.

research Relationship between Serum Concentrations, Hemodynamic Effects, and Cardiovascular Lesions in Dogs Treated with Minoxidil

29 citations , October 1996 in “Toxicology and Applied Pharmacology”

Higher minoxidil doses in dogs cause faster heart rate, lower blood pressure, and heart issues.

research 1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity

5 citations , April 2014 in “Journal of Lipid Research”

This study demonstrates a method to noninvasively assess lipid classes in rodent sebum via high-field proton NMR, observing significant lipid reductions in rats treated with an SCD1 inhibitor.

research Therapeutic Approach for Hair Growth and Regeneration Using Bioactive Formulation Containing Mesenchymal Stromal Cell-Derived Conditioned Medium

January 2023 in “Journal of Cosmetics, Dermatological Sciences and Applications”

In this study, researchers assessed the efficacy of Trichosera® hair serum, containing mesenchymal stromal cells conditioned media, among 40 healthy Indian volunteers, finding significant improvements in hair growth rate, hair density, scalp condition, and reduction in hair fall without notable adverse effects.

research Hemodynamic effects of minoxidil following intravenous infusions in untreated hypertensive patients.

5 citations , February 1996 in “Clinical pharmacology and therapeutics/Clinical pharmacology & therapeutics”

Minoxidil given intravenously caused small changes in diastolic blood pressure and increased heart rate at higher concentrations in patients with high blood pressure.

research Bioequivalence Study of Finasteride

6 citations , December 2011 in “Drug Research”

This study concluded that Flaxin tablets and the reference formulation are bioequivalent in terms of absorption rate and extent when administered as a single 5 mg dose to healthy male volunteers.

research Prevalence of functional disorders of androgen excess in unselected premenopausal women: a study in blood donors

70 citations , February 2012 in “Human Reproduction”

This study found a high prevalence of clinical signs and functional disorders of androgen excess in premenopausal women, with idiopathic hyperandrogenism and idiopathic hirsutism rates similar to PCOS.

research The diagnosis of nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, based on serum basal or post-ACTH stimulation 17-hydroxyprogesterone, can lead to false-positive diagnosis

25 citations , September 2015 in “Clinical Endocrinology”

This study found that diagnosing nonclassic congenital adrenal hyperplasia in women based solely on serum 17OHP measurements can lead to false positives, suggesting the need for urinary steroid profiles and genetic testing for confirmation.

research Hair and Scalp Variation Related to Gender

January 2018 in “Springer eBooks”

Gender affects hair and scalp characteristics, with differences in hormone responses, graying patterns, and trace metals.

research Study of Frontal Hairline Patterns in Spanish Caucasian Women

4 citations , April 2013 in “Actas Dermo-Sifiliográficas”

This study found that hairline measurements in white Spanish women differ from those previously reported for American women, which may be important for hair transplantation evaluations in alopecia cases.

research Gender-linked differences in human skin

205 citations , July 2009 in “Journal of Dermatological Science”

This review discusses gender-linked skin differences, such as hormone metabolism and sebum production, and reports no new findings; it suggests these insights might inform male-specific dermatological treatments or cosmetic products.

research Simultaneous Determination of Selected Steroids with Neuroactive Effects in Human Serum by Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry

5 citations , April 2024 in “ACS Chemical Neuroscience”

This study developed and validated a highly sensitive method using ultrahigh-performance liquid chromatography with tandem mass spectrometry for accurately analyzing nine neuroactive steroids in human serum, which could enhance understanding of disease pathophysiology and support new biomarker and therapeutic discovery.

research Relations between sex hormone level and characters of hair and skin in healthy young men

18 citations , May 1992 in “American Journal of Biological Anthropology”

This study found no general elevation in androgen levels among men predisposed to balding, despite a correlation with the free-to-total testosterone ratio; no link was observed with acne.

research Urinary steroid metabolome shows adrenal, gonadal, and neuroactive steroid dysregulation in adolescents with depression

1 citations , July 2025

In this study, adolescents with depressive symptoms were found to have higher urinary excretion rates of certain steroid metabolites, including corticosterone and adrenal hormones, and a specific metabolite ratio was identified as a potential biomarker for distinguishing these patients from healthy controls.